Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cheng, P.; Gu, Q.; Liu, W.; Zou, J.F.; Ou, Y.Y.; Luo, Z.Y.; Zeng, J.G.
    Synthesis of quinolin-2-one alkaloid derivatives and their inhibitory activities against HIV-1 reverse transcriptase (2011), Molecules, 16, 7649-7661.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.49 (2-amino-5-chlorophenyl)(2-chlorophenyl)methanone
-
 Human immunodeficiency virus 1
2.7.7.49 (2-amino-5-chlorophenyl)(2-fluorophenyl)methanone
-
 Human immunodeficiency virus 1
2.7.7.49 (2-amino-5-chlorophenyl)(phenyl)methanone
-
 Human immunodeficiency virus 1
2.7.7.49 (4S)-6-chloro-4-(cyclopropylethynyl)-4-(trifluoromethyl)-3,4-dihydroquinazolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 2,4,6-trichloroquinoline
-
 Human immunodeficiency virus 1
2.7.7.49 3-(3-methylbut-2-en-1-yl)-4-[(3-methylbut-2-en-1-yl)oxy]quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 3-([3-bromo-2-oxo-5-[(pyridin-3-yloxy)methyl]-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile
-
 Human immunodeficiency virus 1
2.7.7.49 4-chloroaniline
-
 Human immunodeficiency virus 1
2.7.7.49 4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-1-(2,6-dichlorobenzyl)-1,3-dihydro-2H-benzimidazol-2-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-(2-fluorophenyl)quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-(3,5-dimethylphenoxy)quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-(phenylsulfanyl)quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-(phenylsulfinyl)quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-(phenylsulfonyl)quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-phenoxyquinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-phenylquinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-[(3,5-dimethylphenyl)sulfinyl]quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-[(3,5-dimethylphenyl)sulfonyl]-3,4-dihydroquinoxalin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 6-chloro-4-[(3,5-dimethylphenyl)sulfonyl]quinolin-2(1H)-one
-
 Human immunodeficiency virus 1
2.7.7.49 efavirenz
-
 Human immunodeficiency virus 1
2.7.7.49 additional information synthesis and inhibitory activities of quinolin-2-one alkaloid derivatives against HIV-1 reverse transcriptase, molecular docking study, overview Human immunodeficiency virus 1
2.7.7.49 N-(4-chlorophenyl)acetamide
-
 Human immunodeficiency virus 1
2.7.7.49 propan-2-yl 7-methoxy-2-[(methylsulfanyl)methyl]-3-thioxo-3,4-dihydroquinoxaline-1(2H)-carboxylate
-
 Human immunodeficiency virus 1

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.49 Human immunodeficiency virus 1
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.7.7.49 HIV-1 reverse transcriptase
-
 Human immunodeficiency virus 1
2.7.7.49 HIV-1 RT
-
 Human immunodeficiency virus 1

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.49 0.00015
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-(3,5-dimethylphenoxy)quinolin-2(1H)-one
2.7.7.49 0.00021
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one
2.7.7.49 0.0026
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-[(3,5-dimethylphenyl)sulfinyl]quinolin-2(1H)-one
2.7.7.49 0.003
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-phenoxyquinolin-2(1H)-one
2.7.7.49 0.0056
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-(phenylsulfanyl)quinolin-2(1H)-one
2.7.7.49 0.0089
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-(phenylsulfinyl)quinolin-2(1H)-one
2.7.7.49 0.01
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-[(3,5-dimethylphenyl)sulfonyl]quinolin-2(1H)-one
2.7.7.49 0.018
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 4-[(3,5-dimethylphenyl)sulfanyl]quinolin-2(1H)-one
2.7.7.49 0.049
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-(phenylsulfonyl)quinolin-2(1H)-one
2.7.7.49 0.1
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 3-([3-bromo-2-oxo-5-[(pyridin-3-yloxy)methyl]-1,2-dihydropyridin-4-yl]oxy)-5-chlorobenzonitrile
2.7.7.49 0.1
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-phenylquinolin-2(1H)-one
2.7.7.49 0.1
-
 pH and temperature not specified in the publication Human immunodeficiency virus 1 6-chloro-4-(2-fluorophenyl)quinolin-2(1H)-one