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Literature summary extracted from

  • Kong, D.; Zhang, Y.; Yamori, T.; Duan, H.; Jin, M.
    Inhibitory activity of flavonoids against class I phosphatidylinositol 3-kinase isoforms (2011), Molecules, 16, 5159-5167.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.153 Baicalin 10 microM, 35.5% inhibition of isoform PI3Kalpha Homo sapiens
2.7.1.153 luteolin 1 microM, 75.8% inhibition of isoform PI3Kalpha Homo sapiens
2.7.1.153 additional information inhibitory activity of eighteen flavonoids and deduction of their structure-activity relationships. The number of hydroxyl groups in the A and B rings might promote the activity, while loss of C2-C3 double bond might reduce the activity. The results indicate that the flavonoids seem to exhibit more potent activity on PI3Kalpha and delta isoforms compared with that on PI3Kbeta and gamma isoforms Homo sapiens
2.7.1.153 myricetin 1 microM, almost complete inhibition of isoform PI3Kalpha Homo sapiens
2.7.1.153 quercetagetin 1 microM, almost complete inhibition of isoform PI3Kalpha Homo sapiens
2.7.1.153 quercetin 1 microM, 54.1% inhibition of isoform PI3Kalpha Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.153 Homo sapiens
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.153 commercial preparation recombinant isoforms PI3Kalpha, beta, delta and gamma Homo sapiens
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