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Literature summary extracted from

  • Woriedh, M.; Hauber, I.; Martinez-Rocha, A.L.; Voigt, C.; Maier, F.J.; Schroeder, M.; Meier, C.; Hauber, J.; Schaefer, W.
    Preventing Fusarium head blight of wheat and cob rot of maize by inhibition of fungal deoxyhypusine synthase (2011), Mol. Plant Microbe Interact., 24, 619-627.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.5.1.46 drug development fungal DHS is a target for the development of inhibitors, for which CNI-1493 may serve as a lead substance Fusarium graminearum

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.46 DHS gene, DNA and amino acid sequence determination and analysis Triticum aestivum
2.5.1.46 DHS gene, DNA and amino acid sequence determination and analysis Fusarium graminearum

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.46 CNI-1493 inhibition in vitro and in vivo, inhibits germination conidia. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth Fusarium graminearum
2.5.1.46 CNI-1493 inhibition in vitro. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth Triticum aestivum
2.5.1.46 CNI-1493 inhibition in vitro. Although DHS of wheat, fungus, and human can be equally inhibited by the inhibitor CNI-1493 in vitro, application during infection of wheat and maize flowers results in strong inhibition of the pathogen without interference with kernel development, providing the possibiity to selectively inhibit fungal growth without affecting plant growth Zea mays

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.46 41400
-
 x * 41400, about, sequence calculation Triticum aestivum

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Triticum aestivum
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Zea mays
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Fusarium graminearum
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine Fusarium graminearum FG00323.1
-
 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.46 Fusarium graminearum
-
-
-
2.5.1.46 Fusarium graminearum FG00323.1
-
-
-
2.5.1.46 Triticum aestivum
-
-
-
2.5.1.46 Zea mays
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.46 leaf
-
 Triticum aestivum
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Triticum aestivum [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Zea mays [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Fusarium graminearum [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?
2.5.1.46 [eIF5A-precursor]-lysine + spermidine
-
 Fusarium graminearum FG00323.1 [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine
-
 ?

Subunits

EC Number Subunits Comment Organism
2.5.1.46 ? x * 41400, about, sequence calculation Triticum aestivum