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Literature summary extracted from

  • Tang, X.; Ezaki, S.; Fujiwara, S.; Takagi, M.; Atomi, H.; Imanaka, T.
    The tryptophan biosynthesis gene cluster trpCDEGFBA from Pyrococcus kodakaraensis KOD1 is regulated at the transcriptional level and expressed as a single mRNA (1999), Mol. Gen. Genet., 262, 815-821.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
4.1.1.48 expression in Escherichia coli Thermococcus kodakarensis

Organism

EC Number Organism UniProt Comment Textmining
4.1.1.48 Thermococcus kodakarensis Q9YGB5
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
4.1.1.48 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate
-
 Thermococcus kodakarensis 1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
4.1.1.48 indole-3-glycerolphosphate synthase
-
 Thermococcus kodakarensis
4.1.1.48 InGPS
-
 Thermococcus kodakarensis
4.1.1.48 Pk-trpC
-
 Thermococcus kodakarensis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
4.1.1.48 85
-
-
 Thermococcus kodakarensis

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
4.1.1.48 60 95 60°C: about 50% of maximal activity, 95°C: about 45% of maximal activity Thermococcus kodakarensis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
4.1.1.48 5.5
-
-
 Thermococcus kodakarensis

Expression

EC Number Organism Comment Expression
4.1.1.48 Thermococcus kodakarensis a significant increase in trp mRNA level is observed in cells grown in medium depleted of L-tryptophan, compared to cells grown in medium supplemented with L-tryptophan, indicating that expression of the gene cluster is regulated at the transcriptional level up