Literature summary extracted from

Asano, S.; Kitatani, K.; Taniguchi, M.; Hashimoto, M.; Zama, K.; Mitsutake, S.; Igarashi, Y.; Takeya, H.; Kigawa, J.; Hayashi, A.; Umehara, H.; Okazaki, T.
Regulation of cell migration by sphingomyelin synthases: sphingomyelin in lipid rafts decreases responsiveness to signaling by the CXCL12/CXCR4 pathway (2012), Mol. Cell. Biol., 32, 3242-3252.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.8.27	Mus musculus	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
2.7.8.27	MEF cell	-	Mus musculus	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.8.27	phosphatidylcholine + C6-ceramide	-	Mus musculus	C6-sphingomyelin + 1,2-diacyl-sn-glycerol	-	?

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.8.27	SMS	-	Mus musculus

General Information

EC Number	General Information	Comment	Organism
2.7.8.27	malfunction	sphingomyelin synthase (SMS) deficiency promotes cell migration through a CXCL12/CXCR4-dependent signaling pathway involving extracellular signal-regulated kinase activation. In addition, SMS1/SMS2 double-knockout cells have heightened sensitivity to CXCL12. SMS deficiency facilitates relocalization of CXCR4 to lipid rafts, which form platforms for the regulation and transduction of receptor-mediated signaling. Furthermore, SMS deficiency potentiates CXCR4 dimerization, which is required for signal transduction	Mus musculus
2.7.8.27	physiological function	sphingomyelin synthase-generated sphingomyelin is involed in the regulation of cell migration	Mus musculus

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Release 2023.1 (January 2023)