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Literature summary extracted from

  • Wang, Y.; Yang, X.; Yamagata, S.; Yamagata, T.; Sato, T.
    Involvement of Ext1 and heparanase in migration of mouse FBJ osteosarcoma cells (2013), Mol. Cell. Biochem., 373, 63-72.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.224 endoplasmic reticulum membrane Ext1 and Ext2 are type II transmembrane glycoproteins Mus musculus 5789
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2.4.1.225 endoplasmic reticulum membrane Ext1 and Ext2 are type II transmembrane glycoproteins Mus musculus 5789
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.4.1.224 additional information Mus musculus the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone ?
-
 ?
2.4.1.224 additional information Mus musculus BALB/c the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone ?
-
 ?
2.4.1.225 additional information Mus musculus the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone ?
-
 ?
2.4.1.225 additional information Mus musculus BALB/c the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.224 Mus musculus
-
 gene sext1 and ext2
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2.4.1.224 Mus musculus BALB/c
-
 gene sext1 and ext2
-
2.4.1.225 Mus musculus
-
 gene sext1 and ext2
-
2.4.1.225 Mus musculus BALB/c
-
 gene sext1 and ext2
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.4.1.224 glycoprotein Ext1 and Ext2 are type II transmembrane glycoproteins Mus musculus
2.4.1.225 glycoprotein Ext1 and Ext2 are type II transmembrane glycoproteins Mus musculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.224 osteosarcoma cell FBJ, highly metastatic mouse osteosarcoma FBJ-LL cells and the poorly metastatic FBJ-S1 cells are produced from a FBJ virus-induced osteosarcoma Mus musculus
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2.4.1.225 osteosarcoma cell FBJ, highly metastatic mouse osteosarcoma FBJ-LL cells and the poorly metastatic FBJ-S1 cells are produced from a FBJ virus-induced osteosarcoma Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.224 additional information the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone Mus musculus ?
-
 ?
2.4.1.224 additional information the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone Mus musculus BALB/c ?
-
 ?
2.4.1.225 additional information the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone Mus musculus ?
-
 ?
2.4.1.225 additional information the Ext1/Ext2 complex possesses higher glycosyltransferase activity than Ext1 or Ext2 alone Mus musculus BALB/c ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.224 Exostosin1
-
 Mus musculus
2.4.1.224 Exostosin2
-
 Mus musculus
2.4.1.224 EXT1
-
 Mus musculus
2.4.1.224 EXT2
-
 Mus musculus
2.4.1.225 Exostosin1
-
 Mus musculus
2.4.1.225 Exostosin2
-
 Mus musculus
2.4.1.225 EXT1
-
 Mus musculus
2.4.1.225 EXT2
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.4.1.224 malfunction a reduction in either Ext1 or Ext2 can cause a reduction in heparan sulfate biosynthesis, overview. Suppression of Ext1 by siRNA in FBJ-S1 cells results in the decreased expression of heparan sulfate and enhanced motility Mus musculus
2.4.1.224 physiological function Ext1 and Ext2 are tumor suppressors. In the biosynthesis of heparan sulfate, after the attachment of a GlcNAc residue to GlcA-Gal-Gal-Xyl, Ext1 and Ext2 catalyze the subsequent elongation of glycosaminoglycans by alternately adding GlcA and GlcNAc to the end of the growing chain. Involvement of Ext1 and heparanase in migration of FBJ osteosarcoma cells, overview Mus musculus
2.4.1.225 malfunction a reduction in either Ext1 or Ext2 can cause a reduction in heparan sulfate biosynthesis, overview. Suppression of Ext1 by siRNA in FBJ-S1 cells results in the decreased expression of heparan sulfate and enhanced motility Mus musculus
2.4.1.225 physiological function Ext1 and Ext2 are tumor suppressors. In the biosynthesis of heparan sulfate, after the attachment of a GlcNAc residue to GlcA-Gal-Gal-Xyl, Ext1 and Ext2 catalyze the subsequent elongation of glycosaminoglycans by alternately adding GlcA and GlcNAc to the end of the growing chain. Involvement of Ext1 and heparanase in migration of FBJ osteosarcoma cells, overview Mus musculus