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Literature summary extracted from

  • Banerji, S.; Ngo, M.; Lane, C.F.; Robinson, C.A.; Minogue, S.; Ridgway, N.D.
    Oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus requires phosphatidylinositol 4-kinase IIalpha (2010), Mol. Biol. Cell, 21, 4141-4150.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.67 25-hydroxycholesterol activates Golgi/endosome-associated PI4K activity, PI4K activation by 25-hydroxycholesterol is dependent on oxysterol binding protein, overview Cricetulus griseus
2.7.1.67 oxysterol binding protein activates Golgi/endosome-associated PI4K activity, required for PI4K activation by 25-hydroxycholesterol, overview Cricetulus griseus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.67 isozymes PI4KIIalpha or PI4KIIIbeta Cricetulus griseus
2.7.1.67 transient expression of GFP-PI4KIIalpha in CHO cells, the tagged enzyme is present in perinuclear vesicles in control and 25-hydroxycholesterol-treated cells, overview Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.67 cholesterol cholesterol sensitivity of PI4KIIalpha Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.67 endosome
-
 Cricetulus griseus 5768
-
2.7.1.67 endosome
-
 Homo sapiens 5768
-
2.7.1.67 Golgi apparatus
-
 Cricetulus griseus 5794
-
2.7.1.67 Golgi apparatus
-
 Homo sapiens 5794
-
2.7.1.67 Golgi membrane
-
 Cricetulus griseus 139
-
2.7.1.67 Golgi membrane
-
 Homo sapiens 139
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.67 Mg2+ required Cricetulus griseus
2.7.1.67 Mg2+ required Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Cricetulus griseus
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol Homo sapiens
-
 ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.67 Cricetulus griseus
-
-
-
2.7.1.67 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.67 CHO cell
-
 Cricetulus griseus
-
2.7.1.67 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Cricetulus griseus ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?
2.7.1.67 ATP + 1-phosphatidyl-1D-myo-inositol
-
 Homo sapiens ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.67 phosphatidylinositol 4-kinase IIalpha
-
 Cricetulus griseus
2.7.1.67 phosphatidylinositol 4-kinase IIalpha
-
 Homo sapiens
2.7.1.67 PI4K
-
 Cricetulus griseus
2.7.1.67 PI4K
-
 Homo sapiens
2.7.1.67 PI4KIIalpha
-
 Cricetulus griseus
2.7.1.67 PI4KIIalpha
-
 Homo sapiens
2.7.1.67 PtdIns 4-kinase
-
 Cricetulus griseus
2.7.1.67 PtdIns 4-kinase
-
 Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.67 ATP
-
 Cricetulus griseus
2.7.1.67 ATP
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.67 Homo sapiens inactivation of isozyme PI4KIIalpha by expression of siRNAs in HeLa cells additional information
2.7.1.67 Cricetulus griseus inactivation of isozymes PI4KIIalpha and PI4KIIabeta by expression of siRNAs in CHO cells and by RNAi additional information

General Information

EC Number General Information Comment Organism
2.7.1.67 physiological function phosphatidylinositol 4-kinase IIalpha is required for oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus, overview Cricetulus griseus
2.7.1.67 physiological function phosphatidylinositol 4-kinase IIalpha is required for oxysterol binding protein-dependent activation of sphingomyelin synthesis in the Golgi apparatus, overview Homo sapiens