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Literature summary extracted from

  • Witte, C.E.; Whiteley, A.T.; Burke, T.P.; Sauer, J.D.; Portnoy, D.A.; Woodward, J.J.
    Cyclic di-AMP is critical for Listeria monocytogenes growth, cell wall homeostasis, and establishment of infection (2013), mBio, 4, e00282-13.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.1.4.59 membrane transmembrane protein Listeria monocytogenes 16020
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.85 Listeria monocytogenes
-
-
-
3.1.4.59 Listeria monocytogenes Q8YAR3
-
-
3.1.4.59 Listeria monocytogenes ATCC BAA-679 Q8YAR3
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
 Listeria monocytogenes 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?
3.1.4.59 cyclic di-3',5'-adenylate + H2O
-
 Listeria monocytogenes ATCC BAA-679 5'-O-phosphonoadenylyl-(3'->5')-adenosine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.7.85 dacA
-
 Listeria monocytogenes
3.1.4.59 Lmo0052
-
 Listeria monocytogenes
3.1.4.59 PdeA
-
 Listeria monocytogenes

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.7.85 37
-
 assay at Listeria monocytogenes

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.7.85 8
-
 assay at Listeria monocytogenes

General Information

EC Number General Information Comment Organism
2.7.7.85 malfunction reduction of cyclic di-3',5'-adenylate levels by conditional depletion of the di-adenylate cyclase DacA leads to marked decreases in growth rates, both in vitro and in macrophages. Conditional depletion of dacA also leads to increased IFN-beta expression and a concomitant increase in host cell pyroptosis, a result of increased bacteriolysis and subsequent bacterial DNA release Listeria monocytogenes
2.7.7.85 physiological function cyclic di-3',5'-adenylate coordinates bacterial growth, cell wall stability, and responses to stress and plays a crucial role in the establishment of bacterial infection Listeria monocytogenes
3.1.4.59 physiological function overexpression of PdeA leads to marked decreases in growth rates, both in vitro and in infected macrophages. Deletion of pdeA affects bacterial response to acid stress and leads to increased expression of resuscitation-promoting factors. Mutants with altered levels of c-di-AMP have different susceptibilities to peptidoglycan-targeting antibiotics Listeria monocytogenes