Literature summary extracted from

Gill, S.; ONeill, R.; Lewis, R.J.; Connolly, B.A.
Interaction of the family-B DNA polymerase from the archaeon Pyrococcus furiosus with deaminated bases (2007), J. Mol. Biol., 372, 855-863.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
2.7.7.7	hypoxanthine	traces of uracil and hypoxanthine in DNA can lead to inhibition of the polymerase chain reaction by archaeal DNA polymerases	Pyrococcus furiosus
2.7.7.7	Uracil	traces of uracil and hypoxanthine in DNA can lead to inhibition of the polymerase chain reaction by archaeal DNA polymerases	Pyrococcus furiosus

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.7	Pyrococcus furiosus	-	-	-

Purification (Commentary)

EC Number	Purification (Comment)	Organism
2.7.7.7	-	Pyrococcus furiosus

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2.7.7.7	additional information	polymerase binds DNA containing uracil 1.54.5-fold more strongly than hypoxanthine	Pyrococcus furiosus	?	-	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)