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Literature summary extracted from

  • Martinez-Botella, G.; Breen, J.N.; Duffy, J.E.; Dumas, J.; Geng, B.; Gowers, I.K.; Green, O.M.; Guler, S.; Hentemann, M.F.; Hernandez-Juan, F.A.; Joseph-McCarthy, D.; Kawatkar, S.; Larsen, N.A.; Lazari, O.; Loch, J.T.; Macritchie, J.A.; McKenzie, A.R.; Newman, J.V.; Olivier, N.B.; Otterson, L.G.; Owens, A.P.
    Discovery of selective and potent inhibitors of gram-positive bacterial thymidylate kinase (TMK) (2012), J. Med. Chem., 55, 10010-10021.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.9 (3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 (3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 (3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 (3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 (R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 (S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 (S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 (S)-2-(3-fluorophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 (S)-2-(3-fluorophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 (S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 (S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 (S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 (S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
-
 Staphylococcus aureus
2.7.4.9 4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
-
 Streptococcus pneumoniae
2.7.4.9 5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
-
 Staphylococcus aureus
2.7.4.9 5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
-
 Streptococcus pneumoniae
2.7.4.9 TK-666 i.e. 2-(3-bromophenoxy)-4-((R)-3,3-dimethyl-1-((S)-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid Staphylococcus aureus
2.7.4.9 TK-666 i.e. 2-(3-bromophenoxy)-4-((R)-3,3-dimethyl-1-((S)-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid Streptococcus pneumoniae

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.9 Staphylococcus aureus
-
-
-
2.7.4.9 Streptococcus pneumoniae
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.9 ATP + dTMP
-
 Staphylococcus aureus ADP + dTDP
-
 ?
2.7.4.9 ATP + dTMP
-
 Streptococcus pneumoniae ADP + dTDP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.9 thymidylate kinase
-
 Staphylococcus aureus
2.7.4.9 thymidylate kinase
-
 Streptococcus pneumoniae
2.7.4.9 TMK
-
 Staphylococcus aureus
2.7.4.9 TMK
-
 Streptococcus pneumoniae

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.4.9 0.0000001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2.7.4.9 0.0000001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.0000001
-
 IC50 below 0.1 nM, pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
2.7.4.9 0.0000001
-
 IC50 below 0.1 nM, pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.0000001
-
 IC50 below 0.1 nM, pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
2.7.4.9 0.0000002
-
 pH and temperature not specified in the publication Streptococcus pneumoniae TK-666
2.7.4.9 0.0000002
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000002
-
 IC50 below 0.2 nM, pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
2.7.4.9 0.0000003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2.7.4.9 0.0000003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2.7.4.9 0.0000003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
2.7.4.9 0.0000003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(3-(trifluoromethyl)phenoxy)benzoic acid
2.7.4.9 0.0000005
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-bromophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
2.7.4.9 0.0000006
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.0000006
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000006
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000006
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000007
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)hexyl)benzoic acid
2.7.4.9 0.0000007
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-2-cyclohexyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.0000008
-
 pH and temperature not specified in the publication Staphylococcus aureus TK-666
2.7.4.9 0.000001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.000001
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2.7.4.9 0.0000011
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-bromophenoxy)-4-(R)-(2-(1-adamantane)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.0000012
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000013
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-bromophenoxy)-4-((R)-3-ethyl-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2.7.4.9 0.0000016
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)-2-(tetrahydro-2H-pyran-4-yl)ethyl)benzoic acid
2.7.4.9 0.0000025
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.0000028
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-bromophenoxy)-4-((S)-3,3-dimethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.000003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
2.7.4.9 0.000003
-
 IC50 below 3 nM, pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-3-ethyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)pentyl)benzoic acid
2.7.4.9 0.0000083
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1-(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.00001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-piperidin-1-yl)methyl)-2-(m-tolyloxy)benzoic acid
2.7.4.9 0.0000135
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((S)-3-methyl-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000137
-
 pH and temperature not specified in the publication Staphylococcus aureus (3-chlorophenoxy)-4-((R)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
2.7.4.9 0.000018
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)butyl)benzoic acid
2.7.4.9 0.0000183
-
 pH and temperature not specified in the publication Staphylococcus aureus (3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)propyl)benzoic acid
2.7.4.9 0.000028
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-2-(3-bromophenoxy)-4-((3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)methyl)benzoic acid
2.7.4.9 0.0000293
-
 pH and temperature not specified in the publication Staphylococcus aureus 2-(3-chlorophenoxy)-4-((S)-1-((S)-3-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)piperidin-1-yl)ethyl)benzoic acid
2.7.4.9 0.0001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.00015
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0003
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0004
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0006
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(3-bromophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.001
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0012
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(3-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0013
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0015
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(3,5-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0019
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(3-chloro-4-methylphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0021
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(3-chloro-5-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0026
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0027
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-5-methyl-1-(1-(3-(m-tolyloxy)benzyl)piperidin-3-yl)-pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0029
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0032
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(3-fluorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0034
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0051
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.006
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.0085
-
 pH and temperature not specified in the publication Staphylococcus aureus (S)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.009
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.015
-
 pH and temperature not specified in the publication Streptococcus pneumoniae 5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.018
-
 pH and temperature not specified in the publication Streptococcus pneumoniae (R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.024
-
 pH and temperature not specified in the publication Staphylococcus aureus 5-methyl-1-(1-(3-(3-(trifluoromethyl)phenoxy)benzyl)piperidin-3-yl)pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.035
-
 pH and temperature not specified in the publication Staphylococcus aureus 1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.059
-
 pH and temperature not specified in the publication Staphylococcus aureus 5-methyl-1-[1-[3-(4-methylphenoxy)benzyl]piperidin-3-yl]-pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.124
-
 pH and temperature not specified in the publication Staphylococcus aureus 5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.143
-
 pH and temperature not specified in the publication Staphylococcus aureus 1-(1-(3-(4-methoxyphenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.156
-
 pH and temperature not specified in the publication Staphylococcus aureus 5-methyl-1-[1-(3-phenoxybenzyl)piperidin-3-yl]pyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.2
-
 IC50 above 0.2 mM, pH and temperature not specified in the publication Staphylococcus aureus (R)-1-(1-(3-(4-chlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione
2.7.4.9 0.2
-
 IC50 above 0.2 mM, pH and temperature not specified in the publication Staphylococcus aureus (R)-1-(1-(3-(3,4-dichlorophenoxy)benzyl)piperidin-3-yl)-5-methylpyrimidine-2,4(1H,3H)-dione