EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.58 | - |
Trypanosoma brucei |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.58 | 3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | 4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | 4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | 4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | 4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | 4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | 4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Homo sapiens | |
2.5.1.58 | 4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Saccharomyces cerevisiae | |
2.5.1.58 | 4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | - |
Trypanosoma brucei | |
2.5.1.58 | FTI-276 | - |
Homo sapiens | |
2.5.1.58 | FTI-276 | - |
Saccharomyces cerevisiae | |
2.5.1.58 | FTI-276 | - |
Trypanosoma brucei |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.58 | Homo sapiens | - |
- |
- |
2.5.1.58 | Saccharomyces cerevisiae | - |
- |
- |
2.5.1.58 | Trypanosoma brucei | - |
- |
- |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.5.1.58 | 0.00000078 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | FTI-276 | |
2.5.1.58 | 0.00001 | - |
pH 7.5, 30°C | Trypanosoma brucei | FTI-276 | |
2.5.1.58 | 0.000015 | - |
pH 7.5, 30°C | Homo sapiens | FTI-276 | |
2.5.1.58 | 0.00011 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.00025 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.00027 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.00032 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.00046 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.00062 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.00064 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.001 | - |
pH 7.5, 30°C | Saccharomyces cerevisiae | 4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0033 | - |
pH 7.5, 30°C | Homo sapiens | 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0033 | - |
pH 7.5, 30°C | Trypanosoma brucei | 4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0048 | - |
pH 7.5, 30°C | Homo sapiens | 4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0054 | - |
pH 7.5, 30°C | Trypanosoma brucei | 3-(biphenyl-3-yl)-4-cyano-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0055 | - |
pH 7.5, 30°C | Homo sapiens | 4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0069 | - |
pH 7.5, 30°C | Trypanosoma brucei | 4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.007 | - |
pH 7.5, 30°C | Homo sapiens | 4-cyano-3-(4-methoxyphenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0086 | - |
pH 7.5, 30°C | Trypanosoma brucei | 4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0097 | - |
pH 7.5, 30°C | Trypanosoma brucei | 4-cyano-3-[3-(methoxycarbonyl)phenyl]-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.0106 | - |
pH 7.5, 30°C | Trypanosoma brucei | 3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.015 | - |
pH 7.5, 30°C | Homo sapiens | 4-cyano-3-(dibenzo[b,d]furan-1-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.016 | - |
pH 7.5, 30°C | Homo sapiens | 3-(4-chlorophenyl)-4-cyano-5-(isopropylthio)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.02 | - |
pH 7.5, 30°C | Homo sapiens | 4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.029 | - |
pH 7.5, 30°C | Trypanosoma brucei | 4-cyano-3-(4-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.032 | - |
pH 7.5, 30°C | Trypanosoma brucei | 4-cyano-3-(naphthalen-2-yl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid | |
2.5.1.58 | 0.039 | - |
pH 7.5, 30°C | Homo sapiens | 4-cyano-3-(3-fluorophenyl)-5-(propan-2-ylsulfanyl)thiophene-2-carboxylic acid |