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Why is the molybdenum-substituted tungsten-dependent formaldehyde ferredoxin oxidoreductase not active? A quantum chemical study

Liao, R.Z.; J. Biol. Inorg. Chem. 18, 175-181 (2013)

Data extracted from this reference:

Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
1.2.7.B2
Tungsten
tungsten-dependent enzyme, no activity when tungsten is replaced by molybdenum
Pyrococcus furiosus
1.2.7.5
Molybdenum
the enzyme with molybdenum has higher redox potential than that with tungsten
Pyrococcus furiosus
1.2.7.5
Tungsten
dependent on
Pyrococcus furiosus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.7.5
formaldehyde + H2O + oxidized ferredoxin
Pyrococcus furiosus
-
formate + H+ + reduced ferredoxin
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.2.7.B2
Pyrococcus furiosus
-
-
-
1.2.7.5
Pyrococcus furiosus
Q8U1K3
-
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.7.5
formaldehyde + H2O + oxidized ferredoxin
-
722823
Pyrococcus furiosus
formate + H+ + reduced ferredoxin
-
-
-
?
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
1.2.7.B2
Tungsten
tungsten-dependent enzyme, no activity when tungsten is replaced by molybdenum
Pyrococcus furiosus
1.2.7.5
Molybdenum
the enzyme with molybdenum has higher redox potential than that with tungsten
Pyrococcus furiosus
1.2.7.5
Tungsten
dependent on
Pyrococcus furiosus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.2.7.5
formaldehyde + H2O + oxidized ferredoxin
Pyrococcus furiosus
-
formate + H+ + reduced ferredoxin
-
-
?
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.2.7.5
formaldehyde + H2O + oxidized ferredoxin
-
722823
Pyrococcus furiosus
formate + H+ + reduced ferredoxin
-
-
-
?