EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.1.66 | LH3-V5/His fusion protein is expressed in HEK-293 cells | Mus musculus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.4.1.66 | 96000 | - |
x * 96000, LH3-V5/His fusion protein, SDS-PAGE | Mus musculus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.1.66 | Homo sapiens | - |
- |
- |
2.4.1.66 | Mus musculus | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.1.66 | LH3-V5/His fusion protein is purified using nickel-nitrilotriacetic acid-agarose resin column chromatography | Mus musculus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.1.66 | UDP-glucose + 5-(D-galactosyloxy)-L-lysine-procollagen | - |
Mus musculus | UDP + 1,2-D-glucosyl-5-D-(galactosyloxy)-L-lysine-procollagen | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.4.1.66 | ? | x * 96000, LH3-V5/His fusion protein, SDS-PAGE | Mus musculus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.1.66 | LH3 | - |
Mus musculus |
2.4.1.66 | LH3 | - |
Homo sapiens |
2.4.1.66 | lysyl hydroxylase 3 | - |
Homo sapiens |
2.4.1.66 | lysyl hydroxylase 3 | a multifunctional collagen-modifying enzyme possessing lysyl hydroxylase, hydroxylysine galactosyltransferase, and galactosylhydroxylysine-glucosyltransferase activities | Mus musculus |
2.4.1.66 | PLOD3 | - |
Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.4.1.66 | malfunction | an impairment of lysyl hydroxylase 3 function significantly affects type I collagen fibrillogenesis | Mus musculus |
2.4.1.66 | malfunction | lysyl hydroxylase 3-mediated glucosylation occurs at specific sites in collagen, including cross-linking sites, and suppression of this modification results in defective collagen and mineralization | Homo sapiens |
2.4.1.66 | metabolism | lysyl hydroxylase 3 functions as glucosyltransferase in type I collagen | Homo sapiens |
2.4.1.66 | physiological function | the lysyl hydroxylase 3-mediated glucosylation occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in controlling collagen cross-linking, fibrillogenesis, and mineralization | Homo sapiens |
2.4.1.66 | physiological function | the major function of lysyl hydroxylase 3 in osteoblasts is to glucosylate galactosylhydroxylysine residues in type I collagen | Mus musculus |