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Literature summary extracted from

  • Revert-Ros, F.; Lopez-Pascual, E.; Granero-Molto, F.; Macias, J.; Breyer, R.; Zent, R.; Hudson, B.G.; Saadeddin, A.; Revert, F.; Blasco, R.; Navarro, C.; Burks, D.; Saus, J.
    Goodpasture antigen-binding protein (GPBP) directs myofibril formation: identification of intracellular downstream effector 130-kDa GPBP-interacting protein (GIP130) (2011), J. Biol. Chem., 286, 35030-35043.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
2.7.11.9 additional information gpbp-1-/- mice and Tg-hGPBP-1 animals do not display any obvious morphological phenotype, gpbp-1-/- mice also do not show a functional phenotype, whereas Tg-hGPBP-1 mice display reduced endurance that is not attributable to mitochondrial alterations Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.11.9 ATP + [Goodpasture antigen-binding protein] Mus musculus the Goodpasture antigen-binding protein performs autophosphorylation ADP + [Goodpasture antigen-binding phosphoprotein]
-
 ?
2.7.11.9 additional information Mus musculus GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.9 Mus musculus Q9EQG9
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.11.9 myoblast GPBP-1 accumulates in the cytoplasm of differentiating mouse myoblasts prior to myosin synthesis Mus musculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.9 ATP + [Goodpasture antigen-binding protein] the Goodpasture antigen-binding protein performs autophosphorylation Mus musculus ADP + [Goodpasture antigen-binding phosphoprotein]
-
 ?
2.7.11.9 additional information GPBP-1 targets the GPBP-interacting protein of 130 kDa, GIP130, which binds to myosin and promotes its myofibrillar assembly Mus musculus ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.11.9 Goodpasture antigen-binding protein-1
-
 Mus musculus
2.7.11.9 GPBP-1
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.9 ATP
-
 Mus musculus

General Information

EC Number General Information Comment Organism
2.7.11.9 physiological function GPBP-1 is a non-conventional kinase that regulates glomerular basement membrane collagen organization. It targets GIP130, a new myosin-binding protein, and regulates myofibrillogenesis in cultured myoblasts. GPBP-1 is a kinase for structural protein organization at both intracellular and extracellular compartments Mus musculus