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Literature summary extracted from

  • Koehler, C.; Carlier, L.; Veggi, D.; Balducci, E.; Di Marcello, F.; Ferrer-Navarro, M.; Pizza, M.; Daura, X.; Soriani, M.; Boelens, R.; Bonvin, A.M.
    Structural and biochemical characterization of NarE, an iron-containing ADP-ribosyltransferase from Neisseria meningitidis (2011), J. Biol. Chem., 286, 14842-14851.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.2.30 expressed in Escherichia coli Neisseria meningitidis
2.4.2.31 expressed in Escherichia coli Neisseria meningitidis

Protein Variants

EC Number Protein Variants Comment Organism
2.4.2.30 E111D catalytic activity close to wild-type Neisseria meningitidis
2.4.2.30 E120D catalytic activity highly decreased Neisseria meningitidis
2.4.2.30 R7K catalytic activity highly decreased Neisseria meningitidis
2.4.2.31 E111D catalytic activity close to wild-type Neisseria meningitidis
2.4.2.31 E120D catalytic activity highly decreased Neisseria meningitidis
2.4.2.31 R7K catalytic activity highly decreased Neisseria meningitidis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.4.2.30 Fe2+ enzyme binds iron through a Fe-S center, which is crucial for the catalytic activity Neisseria meningitidis
2.4.2.31 Fe2+ enzyme binds iron through a Fe-S center, which is crucial for the catalytic activity Neisseria meningitidis

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.2.30 16000
-
-
 Neisseria meningitidis
2.4.2.31 16000
-
-
 Neisseria meningitidis

Organism

EC Number Organism UniProt Comment Textmining
2.4.2.30 Neisseria meningitidis
-
-
-
2.4.2.31 Neisseria meningitidis
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.2.30 NAD+ + (ADP-D-ribosyl)n-acceptor agmatine as ADPribose acceptor is used Neisseria meningitidis nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?
2.4.2.31 NAD+ + (ADP-D-ribosyl)n-acceptor agmatine as ADPribose acceptor is used Neisseria meningitidis nicotinamide + (ADP-D-ribosyl)n+1-acceptor
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.2.30 NarE
-
 Neisseria meningitidis
2.4.2.31 NarE
-
 Neisseria meningitidis

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.4.2.30 30
-
 assay at Neisseria meningitidis
2.4.2.31 30
-
 assay at Neisseria meningitidis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.4.2.30 7.5
-
 assay at Neisseria meningitidis
2.4.2.31 7.5
-
 assay at Neisseria meningitidis