EC Number | Organism | UniProt | Comment | Textmining |
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4.2.1.144 | Amycolatopsis mediterranei | - |
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EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
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4.2.1.144 | 5-amino-5-deoxy-3-dehydroshikimate | - |
Amycolatopsis mediterranei | 3-amino-5-hydroxybenzoate + H2O | - |
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EC Number | General Information | Comment | Organism |
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4.2.1.144 | physiological function | enzyme is part of the aminoshikimate pathway of formation of 3-amino-5-hydroxybenzoic acid, the precursor of ansamycin and other antibiotics. Nitrogenous precursor Kanosamine is phosphorylated and converted into 1-deoxy-1-imino-erythrose 4-phosphate, the substrate for the formation of 3,4-dideoxy-4-amino-D-arabino-seduheptulosonic acid 7-phosphate. This is converted via 5-deoxy-5-aminodehydroquinic acid and 5-deoxy-5-aminodehydroshikimic acid into 3-amino-5-hydroxybenzoic acid. 3-amino-5-hydroxybenzoic acid synthase seems to have two catalytic functions. As a homodimer, it catalyzes the last reaction in the pathway, the aromatization of 5-deoxy-5-aminodehydroshikimic acid, and at the beginning of the pathway in a complex with the oxidoreductase RifL it catalyzes the transamination of UDP-3-keto-D-glucose | Amycolatopsis mediterranei |