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Literature summary extracted from

  • Miyamoto, Y.; Ohta, S.; Johdo, O.; Nagamatsu, Y.; Yoshimoto, A.
    Production of a new hybrid anthracycline 4-O-methylepelmycin by heterologous expression of dnrK in epelmycin-producing Streptomyces violaceus (2000), J. Antibiot., 53, 828-836.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.1.1.292 synthesis production of a new hybrid anthracycline antibiotic. Expression in Streptomyces violaceus pMK100 (epelmycin producer). The transformant produces the hybrid anthracycline antibiotic 7-O-L-hodosaminyl-4-O-methyl-epsilon-rhodomycinone (4-O-methylepelmycin D) together with host epelmycins when cultured in antibiotic production medium in the presence of thiostrepton. Attempts on production of hybrid 4-O-methylaclarubicin and 4-O-methyl-l-deoxyobelmycin by the transformants of aclarubicin and 1-deoxyobelmycin producers are unsuccessful Streptomyces peucetius

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.1.1.292 expression in Streptomyces violaceus pMK100 (epelmycin producer). The transformant produces the hybrid anthracycline antibiotic 7-O-L-rhodosaminyl-4-O-methyl-epsilon-rhodomycinone (4-O-methylepelmycin D) together with host epelmycins when cultured in antibiotic production medium in the presence of thiostrepton. Attempts on production of hybrid 4-O-methylaclarubicin and 4-O-methyl-1-deoxyobelmycin by the transformants of aclarubicin and 1-deoxyobelmycin producers are unsuccessful Streptomyces peucetius

Organism

EC Number Organism UniProt Comment Textmining
2.1.1.292 Streptomyces peucetius
-
-
-

Synonyms

EC Number Synonyms Comment Organism
2.1.1.292 DnrK
-
 Streptomyces peucetius