Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Arora, N.; Banerjee, A.K.; Murty, U.S.
    In silico characterization of shikimate kinase of Shigella flexneri: a potential drug target (2010), Interdiscip. Sci., 2, 280-290.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.7.1.71 drug development the enzyme is an attractive drug target Shigella flexneri

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.71 additional information enzyme structure analysis and modeling for rational drug designing, overview Shigella flexneri

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.1.71 Mg2+ required Shigella flexneri

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.7.1.71 ATP + shikimate Shigella flexneri
-
 ADP + 3-phosphoshikimate
-
 ?
2.7.1.71 ATP + shikimate Shigella flexneri 8401
-
 ADP + 3-phosphoshikimate
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.71 Shigella flexneri
-
 serotype 5b
-
2.7.1.71 Shigella flexneri 8401
-
 serotype 5b
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.71 ATP + shikimate
-
 Shigella flexneri ADP + 3-phosphoshikimate
-
 ?
2.7.1.71 ATP + shikimate
-
 Shigella flexneri 8401 ADP + 3-phosphoshikimate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.1.71 ? x * 26973.6, sequence calculation Shigella flexneri
2.7.1.71 More prediction of enzyme secondary sstructure, overview Shigella flexneri

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.1.71 ATP
-
 Shigella flexneri

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.1.71 Shigella flexneri sequence calculation
-
 5.61

General Information

EC Number General Information Comment Organism
2.7.1.71 additional information comparative modeling approach, molecular dynamics calculations using the Escherichia coli structure as template, prediction of in silico and disordered regions, enzyme structure analysis and modeling, overview Shigella flexneri