Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Cheong, J.; Virshup, D.
    Casein kinase 1: complexity in the family (2011), Int. J. Biochem. Cell Biol., 43, 465-469.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.11.1 pyrvinium an FDA-approved anthelmintic drug, a very potent allosteric activator of CKalpha that inhibits the Wnt/beta-catenin pathway by increasing phosphorylation and degradation of beta-catenin, along with other key substrates. it is specific for CK1alpha versus other forms of CK1 Homo sapiens

Application

EC Number Application Comment Organism
2.7.11.1 medicine the CK1 family of serine/threonine kinases appears to be a viable therapeutic target for the treatment of a number of human malignancies like jet-lag and cancer, overview Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.11.1 gene transcript organization of human CK1 isoforms and their splice variants, overview Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.11.1 Homo sapiens
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
2.7.11.1 phosphoprotein CK1 is regulated by posttranslational modification, including autophosphorylation Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
2.7.11.1 ATP + a [protein]-(L-serine/L-threonine) = ADP + a [protein]-(L-serine/L-threonine) phosphate the CK1 family shows a strong preference both in vitro and in vivo for primed, pre-phosphorylated substrates. CK1 family members prefer acidic substrates in vitro, most notably those with acidic residues in the N-3 position, e.g. D-X-X-S/T. The most effective motif contains a phospho-residue in the N-3 position, such as pS/pT-X-X-S/T, where pS/pT refers to a phospho-serine or phospho-threonine, X refers to any amino acid, and the underlined residues refer to the target site Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.11.1 ATP + AIB1 protein phosphorylation at S601 by isozyme CK1delta Homo sapiens ADP + phosphorylated AIB1 protein
-
?
2.7.11.1 ATP + beta-catenin
-
Homo sapiens ADP + phosphorylated beta-catenin by isozymes CK1delta and CK1epsilon ?
2.7.11.1 ATP + calmodulin phosphorylation by isozyme CK1alpha Homo sapiens ADP + phosphorylated calmodulin
-
?
2.7.11.1 ATP + CARMA1 protein i.e. CARD11 protein, phosphorylation at S608 by isozyme CK1alpha Homo sapiens ADP + phosphorylated CARMA1
-
?
2.7.11.1 ATP + Cdc25A phosphorylation at S79 and S82 by isozyme CK1alpha Homo sapiens ADP + phosphorylated Cdc25A
-
?
2.7.11.1 ATP + Dnmt1 protein phosphorylation at S147 by isozymes CK1delta and CK1epsilon Homo sapiens ADP + phosphorylated Dnmt1 protein
-
?
2.7.11.1 ATP + FADD protein phosphorylation at S194 by isozyme CK1alpha Homo sapiens ADP + phosphorylated FADD protein
-
?
2.7.11.1 ATP + IFNAR1 protein phosphorylation at S535 by isozyme CK1alpha Homo sapiens ADP + phosphorylated IFNAR1 protein
-
?
2.7.11.1 ATP + KLP10A protein phosphorylation at S573 by isozyme CK1alpha Homo sapiens ADP + phosphorylated KLP10A protein
-
?
2.7.11.1 ATP + PHLPP1 protein phosphorylation at T851 by isozyme CK1alpha Homo sapiens ADP + phosphorylated PHLPP1 protein
-
?
2.7.11.1 ATP + PKD2 protein phosphorylation at S244 by isozymes CK1alpha, CK1delta, and CK1epsilon Homo sapiens ADP + phosphorylated PKD2 protein
-
?
2.7.11.1 ATP + Rec8 protein phosphorylation at S412 by isozyme CK1delta and CK1epsilon, and at S400, S402, S404, S410, T414, and S416 Homo sapiens ADP + phosphorylated Rec8 protein
-
?
2.7.11.1 ATP + SLR1 protein phosphorylation at S196 and SS510 Homo sapiens ADP + phosphorylated SLR1 protein
-
?
2.7.11.1 ATP + Snail protein phosphorylation at S104 and S07 by isozyme CK1epsilon Homo sapiens ADP + phosphorylated Snail protein
-
?
2.7.11.1 ATP + YAP protein phosphorylation at S384 and S387 by isozymes CK1delta and CK1epsilon Homo sapiens ADP + phosphorylated YAP protein
-
?
2.7.11.1 additional information CK1 exhibits autophosphorylation activity Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
2.7.11.1 monomer
-
Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.11.1 casein kinase 1
-
Homo sapiens
2.7.11.1 CK1
-
Homo sapiens
2.7.11.1 CK1alpha
-
Homo sapiens
2.7.11.1 CK1delta
-
Homo sapiens
2.7.11.1 CK1epsilon
-
Homo sapiens
2.7.11.1 CK1gamma
-
Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.7.11.1 ATP
-
Homo sapiens

pI Value

EC Number Organism Comment pI Value Maximum pI Value
2.7.11.1 Homo sapiens CK1 family members are generally positively charged, with isoelectric points above 9
-
additional information

General Information

EC Number General Information Comment Organism
2.7.11.1 evolution CK1 belongs to the CK1 family of serine/threonine kinases, CK1 is evolutionary conserved within eukaryotes Homo sapiens
2.7.11.1 metabolism roles of CK1 in Wnt signaling, detailed overview Homo sapiens
2.7.11.1 additional information structure of catalytic sites of CK1 isozymes, overview. A spontaneously occurring human mutation of a CK1 priming site in PER2, Ser662, leads to decreased phosphorylation of stabilizing sites in PER2 and accelerated circadian rhythms Homo sapiens
2.7.11.1 physiological function the CK1 family of serine/threonine kinases regulates diverse cellular processes, including circadian rhythms, Wnt signaling, membrane trafficking, cytoskeleton maintenance, DNA replication, DNA damage response, RNA metabolism and parasitic infections, through binding to and phosphorylation a myriad of protein substrates. CK1 isoforms are key regulators of several cellular growth and survival processes, including Wnt and Hedgehog signaling, cell cycle control, DNA repair and apoptosis. CK1 is involved in scaffold binding and kinase regulation in Wnt signaling and circadian rhythms. CK1is itself regulated by posttranslationalmodification, including autophosphorylation. CK1alpha is a essential component of the Wnt/beta-catenin signaling pathway. It binds to axin, and phosphorylates beta-catenin on serine 45, thereby creating a GSK3 recognition site and ultimately causing the degradation of beta-catenin. CK1delta/epsilon are implicated in colon, pancreatic and breast cancer progression via the suppression of apoptosis, regulation of mitotic function, and/or activation of beta-catenin signaling. CK1epsilon is a pro-survival factor in cancer cells in vitro Homo sapiens