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Literature summary extracted from

  • Nomura, K.H.; Murata, D.; Hayashi, Y.; Dejima, K.; Mizuguchi, S.; Kage-Nakadai, E.; Gengyo-Ando, K.; Mitani, S.; Hirabayashi, Y.; Ito, M.; Nomura, K.
    Ceramide glucosyltransferase of the nematode Caenorhabditis elegans is involved in oocyte formation and in early embryonic cell division (2011), Glycobiology, 21, 834-848.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.80 expressed in GM95 cells deficient in glycosphingolipids Caenorhabditis elegans

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.80 Caenorhabditis elegans
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.80 UDP-glucose + ceramide
-
 Caenorhabditis elegans UDP + glucosylceramide
-
 ?
2.4.1.80 UDP-glucose + N-(epsilon-7-nitrobenz-2-oxa-1,3-diazol-4-yl-aminocaproyl)-D-erythro-sphingosine
-
 Caenorhabditis elegans ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.4.1.80 ceramide glucosyltransferase
-
 Caenorhabditis elegans
2.4.1.80 cgt-1
-
 Caenorhabditis elegans
2.4.1.80 cgt-2
-
 Caenorhabditis elegans
2.4.1.80 cgt-3
-
 Caenorhabditis elegans
2.4.1.80 cgt-3 isoforms with highest activity Caenorhabditis elegans
2.4.1.80 GlcT
-
 Caenorhabditis elegans
2.4.1.80 UDP-glucose ceramide glucosyltransferase
-
 Caenorhabditis elegans
2.4.1.80 Ugcg
-
 Caenorhabditis elegans
2.4.1.80 uridine diphosphate (UDP)-glucose:N-acylsphingosine D-glucosyltransferase
-
 Caenorhabditis elegans

General Information

EC Number General Information Comment Organism
2.4.1.80 malfunction when each gene function is disrupted, the brood size of the animal markedly decreases and abnormal oocytes and multinucleated embryos are formed. Knockdown of the germline expression of gene cgt-3 results in abnormal oocyte formation and abnormal embryonic cell division Caenorhabditis elegans
2.4.1.80 physiological function the Ugcg gene is indispensable in the gremlin in oocyte formation and early embryonic division Caenorhabditis elegans