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Literature summary extracted from

  • Alderwick, L.J.; Lloyd, G.S.; Lloyd, A.J.; Lovering, A.L.; Eggeling, L.; Besra, G.S.
    Biochemical characterization of the Mycobacterium tuberculosis phosphoribosyl-1-pyrophosphate synthetase (2011), Glycobiology, 21, 410-425.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.6.1 phosphate the enzyme requires the presence of phosphate at a concentration of 50 mM for full activation Mycobacterium tuberculosis

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.6.1 expressed in Escherichia coli C41 cells Mycobacterium tuberculosis

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.6.1 ADP strong inhibitor Mycobacterium tuberculosis

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.6.1 0.0082
-
D-ribose 5-phosphate at pH 7.5 and 37°C Mycobacterium tuberculosis

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.6.1 cytoplasm
-
Mycobacterium tuberculosis 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.6.1 Mg2+ required Mycobacterium tuberculosis
2.7.6.1 Mn2+ required Mycobacterium tuberculosis
2.7.6.1 additional information Mn2+ and Mg2+ cannot be replaced by Ca2+ Mycobacterium tuberculosis

Organism

EC Number Organism UniProt Comment Textmining
2.7.6.1 Mycobacterium tuberculosis
-
-
-
2.7.6.1 Mycobacterium tuberculosis H37Rv
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.6.1 Ni2+-NTA agarose column chromatography Mycobacterium tuberculosis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.6.1 5'-adenylyl-beta,gamma-imidodiphosphate + D-ribose 5-phosphate
-
Mycobacterium tuberculosis ?
-
?
2.7.6.1 5'-adenylyl-beta,gamma-imidodiphosphate + D-ribose 5-phosphate
-
Mycobacterium tuberculosis H37Rv ?
-
?
2.7.6.1 ATP + D-ribose 5-phosphate
-
Mycobacterium tuberculosis AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
ir
2.7.6.1 ATP + D-ribose 5-phosphate
-
Mycobacterium tuberculosis H37Rv AMP + 5-phospho-alpha-D-ribose 1-diphosphate
-
ir

Subunits

EC Number Subunits Comment Organism
2.7.6.1 hexamer
-
Mycobacterium tuberculosis

Synonyms

EC Number Synonyms Comment Organism
2.7.6.1 phosphoribosyl-1-pyrophosphate synthetase
-
Mycobacterium tuberculosis
2.7.6.1 PRPP synthetase
-
Mycobacterium tuberculosis
2.7.6.1 PrsA
-
Mycobacterium tuberculosis

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.6.1 6.5
-
-
Mycobacterium tuberculosis

pH Range

EC Number pH Minimum pH Maximum Comment Organism
2.7.6.1 4.5 9.5 the enzyme shows activity across a broad range of pH levels (4.5-9.5) and is only found to be inactive at high pH 10.5 Mycobacterium tuberculosis

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.7.6.1 0.522
-
ADP at pH 7.5 and 37°C Mycobacterium tuberculosis

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.6.1 7430
-
D-ribose 5-phosphate at pH 7.5 and 37°C Mycobacterium tuberculosis