EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.3.2 | (2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | organotellurium inhibits creatine kinase activity by two different mechanisms: competition with ADP and oxidation of critical sulfhydryl groups for the functioning of the enzyme | Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.3.2 | 0.61 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 0.67 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 0.7 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 0.87 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.11 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.15 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.32 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.34 | - |
phosphocreatine | no organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.37 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.38 | - |
ATP | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.41 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.72 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.73 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.75 | - |
ATP | no organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 1.94 | - |
ATP | 0.005 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.03 | - |
ATP | 0.020 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.04 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.1 | - |
ATP | 0.005 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.1 | - |
ATP | no organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.49 | - |
ATP | 0.020 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.82 | - |
ATP | no organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.84 | - |
ATP | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 3.15 | - |
ATP | no organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 3.19 | - |
ATP | no organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 3.26 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 3.34 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 3.54 | - |
phosphocreatine | no organotellurium, preincubation time 30 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 3.55 | - |
ATP | no organotellurium, preincubation time 5 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 3.92 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 5.3 | 6 | ATP | 0.005 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 5.77 | - |
phosphocreatine | 0.005 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 6.43 | - |
phosphocreatine | 0.020 mM organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 6.68 | - |
ATP | 0.005 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 8.97 | - |
phosphocreatine | no organotellurium, preincubation time 30 min, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 17.52 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, cytosolic fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 20 | - |
ATP | 0.020 mM organotellurium, preincubation time 5 min, mitochondrial fraction, including reduced glutathione (GSH), pH 7.5, 37°C | Rattus norvegicus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.3.2 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.3.2 | ADP + phosphocreatine | - |
Rattus norvegicus | ATP + creatine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.3.2 | creatine kinase | - |
Rattus norvegicus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.7.3.2 | 37 | - |
assay at | Rattus norvegicus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
2.7.3.2 | 7.5 | - |
assay at | Rattus norvegicus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.3.2 | 2.37 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 2.53 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 5.02 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 5.46 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 5.67 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 5.78 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 6.49 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 7.1 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 7.18 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 7.5 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 7.56 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 30 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 8 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 8.12 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 8.2 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 8.22 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 30 min, ADP variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 8.69 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 8.76 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 9.65 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 10.25 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 10.55 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.005 mM organotellurium, preincubation time 5 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 15.45 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, ADP variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 16 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min, phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 16.15 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, mitochondrial fraction, pH 7.5, 37°C | Rattus norvegicus | |
2.7.3.2 | 16.46 | - |
(2Z)-3-butyl-1-phenyl-2-(phenyltellanyl)oct-2-en-1-one | 0.020 mM organotellurium, preincubation time 5 min including reduced glutathione (GSH), phosphocreatine variable, cytosolic fraction, pH 7.5, 37°C | Rattus norvegicus |