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Literature summary extracted from

  • Leite, T.C.; Coelho, R.G.; Da Silva, D.; Coelho, W.S.; Marinho-Carvalho, M.M.; Sola-Penna, M.
    Lactate downregulates the glycolytic enzymes hexokinase and phosphofructokinase in diverse tissues from mice (2011), FEBS Lett., 585, 92-98.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
2.7.1.1 Insulin stimulating effect is abolished when lactate is added Mus musculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.1.1 Lactate lactate indirectly inhibits hexokinase activity, which results from its cellular redistribution, attributed to alterations of hexokinase structure. No modulation of hexokinase activity in heart or kidney Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.1 Mus musculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.1 heart
-
 Mus musculus
-
2.7.1.1 kidney
-
 Mus musculus
-
2.7.1.1 liver
-
 Mus musculus
-
2.7.1.1 muscle
-
 Mus musculus
-

Synonyms

EC Number Synonyms Comment Organism
2.7.1.1 hexokinase
-
 Mus musculus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.7.1.1 37
-
 assay at Mus musculus

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.7.1.1 7.4
-
 assay at Mus musculus