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Literature summary extracted from

  • Gruber, J.; See Too, W.C.; Wong, M.T.; Lavie, A.; McSorley, T.; Konrad, M.
    Balance of human choline kinase isoforms is critical for cell cycle regulation: implications for the development of choline kinase-targeted cancer therapy (2012), FEBS J., 279, 1915-1928.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.7.1.32 cytoplasm isoform CKalpha Homo sapiens 5737
-
2.7.1.32 nucleoplasm isoform CKalpha Homo sapiens 5654
-
2.7.1.32 nucleus nuclear localization probability of 60.9% is detected for isoform CKalpha2 and of 52.2% for CKalpha1 Homo sapiens 5634
-

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.32 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.32 HeLa cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.32 ATP + choline
-
 Homo sapiens ADP + phosphocholine
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.32 CKalpha1 isoform Homo sapiens
2.7.1.32 CKalpha2 isoform Homo sapiens
2.7.1.32 CKbeta1 isoform Homo sapiens

General Information

EC Number General Information Comment Organism
2.7.1.32 malfunction silencing of CKalpha leads to a lethal phenotype with aberrant mitotic arrest and subsequent apoptosis, and is rescued by simultaneous knockdown of CKalpha and CKbeta isoforms Homo sapiens
2.7.1.32 physiological function levels of CKalpa and CKbeta play an essential role in progression through mitosis, but not in resting cells or during DNA replication Homo sapiens