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Literature summary extracted from

  • Passera, E.; Campanini, B.; Rossi, F.; Casazza, V.; Rizzi, M.; Pellicciari, R.; Mozzarelli, A.
    Human kynurenine aminotransferase II--reactivity with substrates and inhibitors (2011), FEBS J., 278, 1882-1900.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.6.1.7
-
 Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.6.1.7 Y142F active site mutation Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.6.1.7 (R)-2-amino-4-(4-(ethylsulfonyl)phenyl)-4-oxobutanoic acid 71% inhibition at 1 mM, 63% inhibition at 0.1 mM, poor substrate that undergo slow transamination, KM-value 4.5 mM, Kcat-value 0.15 1/sec, pH 7.5, 25°C Homo sapiens
2.6.1.7 cysteine sulfinate poor substrate that undergoes slow transamination, KM-value 12.3 mM, pH 7.5, 25°C Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.6.1.7 0.96
-
 L-kynurenine discontinuous assay, pH 7.5, 45°C Homo sapiens
2.6.1.7 1.2
-
 2-oxoglutarate pH not specified in the publication, temperature not specified in the publication Homo sapiens
2.6.1.7 2.09
-
 L-kynurenine continuous assay, pH 7.5, 45°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.6.1.7 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.6.1.7
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.6.1.7 brain
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.6.1.7 L-kynurenine + 2-oxoglutarate
-
 Homo sapiens kynurenic acid + L-glutamate + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.6.1.7 kynurenine aminotransferase II
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.6.1.7 1.8
-
 L-kynurenine continuous assay, pH 7.5, 45°C Homo sapiens
2.6.1.7 2.2
-
 L-kynurenine discontinuous assay, pH 7.5, 45°C Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
2.6.1.7 pyridoxal 5'-phosphate
-
 Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.6.1.7 0.013
-
 cysteine sulfinate 17.2 mM dissociation constant for dissociation of the inhibitor from the enzyme substrate complex, pH 7.5, 25°C Homo sapiens

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.6.1.7 0.002
-
 pH 7.5, 25°C Homo sapiens cysteine sulfinate