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Literature summary extracted from

  • Weng, T.; Karmouty-Quintana, H.; Garcia-Morales, L.J.; Molina, J.G.; Pedroza, M.; Bunge, R.R.; Bruckner, B.A.; Loebe, M.; Seethamraju, H.; Blackburn, M.R.
    Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease (2013), FASEB J., 27, 2013-2026.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.1.74 quantitative RT-PCR expression analysis Mus musculus
2.7.1.74 quantitative RT-PCR expression analysis Homo sapiens

Protein Variants

EC Number Protein Variants Comment Organism
2.7.1.74 additional information for enzyme knockout, MLE12 cells are transfected with DCK siRNA Mus musculus

Organism

EC Number Organism UniProt Comment Textmining
2.7.1.74 Homo sapiens
-
-
-
2.7.1.74 Mus musculus
-
 Ada-/- mice
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.7.1.74 MLE-12 cell
-
 Mus musculus
-
2.7.1.74 pulmonary epithelial cell
-
 Mus musculus
-
2.7.1.74 pulmonary epithelial cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.1.74 NTP + deoxyadenosine
-
 Mus musculus NDP + dAMP
-
 ?
2.7.1.74 NTP + deoxyadenosine
-
 Homo sapiens NDP + dAMP
-
 ?
2.7.1.74 NTP + deoxycytidine
-
 Homo sapiens NDP + dCMP
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.1.74 dCK
-
 Mus musculus
2.7.1.74 dCK
-
 Homo sapiens

Expression

EC Number Organism Comment Expression
2.7.1.74 Mus musculus the enzyme is hypoxia-induced up
2.7.1.74 Homo sapiens the enzyme is hypoxia-induced up

General Information

EC Number General Information Comment Organism
2.7.1.74 malfunction inhibition of the enzyme results in diminished dAdomediated apoptosis in the lungs Homo sapiens
2.7.1.74 malfunction inhibition of the enzyme results in diminished deoxyadenosine-mediated apoptosis in the lungs Mus musculus
2.7.1.74 physiological function deoxycitidine kinase is a major enzyme for deoxyadenosine phosphorylation. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease, hypoxia is a regulator of the enzyme Homo sapiens
2.7.1.74 physiological function deoxycitidine kinase is a major enzyme for deoxyadenosine phosphorylation. Hypoxia-induced deoxycytidine kinase expression contributes to apoptosis in chronic lung disease, hypoxia is a regulator of the enzyme. Activating the dAdo-DCK-dATP pathway directly results in increased apoptosis in the lungs of mice with air-space enlargement, the dAdo-DCK pathway is activated in the lungs of Ada-/- mice, overview Mus musculus