EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.7.7 | additional information | dyskinetoplastid bloodstream form parasites produced during RNAi are not viable, disruption of network-free minicircle replication precedes parasite death | Trypanosoma brucei |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.7 | Trypanosoma brucei | - |
- |
- |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.7 | kDNA replication protein | - |
Trypanosoma brucei |
2.7.7.7 | mitochondrial DNA polymerase | - |
Trypanosoma brucei |
2.7.7.7 | POLIB | - |
Trypanosoma brucei |
2.7.7.7 | POLIC | - |
Trypanosoma brucei |
2.7.7.7 | POLID | - |
Trypanosoma brucei |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.7.7 | malfunction | silencing of each polymerase, of mitochondrial DNA polymerases IB, IC, and ID, is lethal, resulting in kDNA loss, persistence of prereplication DNA monomers, and collapse of the mitochondrial membrane potential. Kinetics of kDNA loss during DNA polymerase silencing, overview | Trypanosoma brucei |
2.7.7.7 | physiological function | the parasite's single mitochondrion contains a unique catenated mitochondrial DNA network called kinetoplast DNA (kDNA) that is composed of minicircles and maxicircles. Three kDNA replication proteins (mitochondrial DNA polymerases IB, IC, and ID) are required for bloodstream form parasite viability | Trypanosoma brucei |