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Literature summary extracted from

  • Schulz, N.; Himmelbauer, H.; Rath, M.; van Weeghel, M.; Houten, S.; Kulik, W.; Suhre, K.; Scherneck, S.; Vogel, H.; Kluge, R.; Wiedmer, P.; Joost, H.G.; Schuermann, A.
    Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis (2011), Endocrinology, 152, 4641-4651.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.35 gene hadh, quantitative real-time PCR expression analysis Mus musculus

Protein Variants

EC Number Protein Variants Comment Organism
1.1.1.35 additional information generation of hadh knockout mice by insertion of gene-trap vector pGT0Lxf in the ES cell line E14Tg2a.4, deletion of hadh results in a defective enzymatic activity of SCHAD, phenotype, overview. Deletion of hadh reduces body weight and adipose tissue depots, and leads to impaire thermogenesis Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+ Mus musculus
-
 3-oxoacyl-CoA + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.35 Mus musculus
-
 gene hadh
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.35 (S)-3-hydroxyacyl-CoA + NAD+
-
 Mus musculus 3-oxoacyl-CoA + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.35 medium- and short-chain-3-hydroxyacyl-CoA dehydrogenase
-
 Mus musculus
1.1.1.35 medium- and short-chain-3-hydroxyacyl-coenzyme A dehydrogenase
-
 Mus musculus
1.1.1.35 SCHAD
-
 Mus musculus
1.1.1.35 short-chain L-3-hydroxyacyl-CoA dehydrogenase
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.35 NAD+
-
 Mus musculus

General Information

EC Number General Information Comment Organism
1.1.1.35 malfunction mice lacking SCHAD, hadh-/-, display a lower body weight and a reduced fat mass in comparison with hadh+/+ mice under high-fat diet conditions, presumably due to an impaired fuel efficiency, the loss of acylcarnitines via the urine, and increased body temperature. Food intake, total energy expenditure, and locomotor activity are not altered in knockout mice Mus musculus
1.1.1.35 metabolism the enzyme catalyzes the third reaction of the mitochondrial beta-oxidation cascade, the oxidation of 3-hydroxyacyl-CoA to 3-ketoacyl-CoA, for medium-andshort-chain fatty acids Mus musculus
1.1.1.35 physiological function the enzyme is involved in thermogenesis, in the maintenance of body weight, and in the regulation of nutrient-stimulated insulin secretion. It plays an important role in adaptive thermogenesis Mus musculus