EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.7.1 | Drosophila melanogaster | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.7.1 | brain | the enzyme localizes in photoreceptor and central brain synapses | Drosophila melanogaster | - |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.7.1 | nicotinamide mononucleotide adenylyltransferase | - |
Drosophila melanogaster |
2.7.7.1 | NMNAT | - |
Drosophila melanogaster |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.7.1 | malfunction | enzyme loss results in ubiquitination, mislocalization and aggregation of the Bruchpilot protein, and subsequent active zone degeneration | Drosophila melanogaster |
2.7.7.1 | physiological function | the enzyme is required for maintaining active zone structural integrity in Drosophila by interacting with the active zone protein Bruchpilot and shielding it from activity-induced ubiquitin-proteasome-mediated degradation. The enzyme specifically maintains active zone structure by direct protein-protein interaction | Drosophila melanogaster |