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Literature summary extracted from

  • Herrera-Valencia, V.A.; Macario-Gonzalez, L.A.; Casais-Molina, M.L.; Beltran-Aguilar, A.G.; Peraza-Echeverria, S.
    In silico cloning and characterization of the glycerol-3-phosphate dehydrogenase (GPDH) gene family in the green microalga Chlamydomonas reinhardtii (2012), Curr. Microbiol., 64, 477-485.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.8 genes CrGPDH1, CrGPDH2, and CrGPDH3, DNA and amino acid sequence determination and analysis, phylogenetic analysis Chlamydomonas reinhardtii

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.8 cytoplasm
-
 Chlamydomonas reinhardtii 5737
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.8 sn-glycerol 3-phosphate + NAD+ Chlamydomonas reinhardtii
-
 glycerone phosphate + NADH + H+
-
 r
1.1.1.8 sn-glycerol 3-phosphate + NAD+ Chlamydomonas reinhardtii CC-125
-
 glycerone phosphate + NADH + H+
-
 r

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.8 Chlamydomonas reinhardtii
-
 three GPDH genes, CrGPDH1, CrGPDH2, and CrGPDH3
-
1.1.1.8 Chlamydomonas reinhardtii CC-125
-
 three GPDH genes, CrGPDH1, CrGPDH2, and CrGPDH3
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.8 sn-glycerol 3-phosphate + NAD+
-
 Chlamydomonas reinhardtii glycerone phosphate + NADH + H+
-
 r
1.1.1.8 sn-glycerol 3-phosphate + NAD+
-
 Chlamydomonas reinhardtii CC-125 glycerone phosphate + NADH + H+
-
 r

Subunits

EC Number Subunits Comment Organism
1.1.1.8 More each one of the three CrGPDHs has a bi-domain protein structure: a GPDH domain of about 350 amino acids located at the C terminus, and a phosphoserine phosphatase (SerB) domain of about 200 amino acids at the N terminus. The GPDH domain of all three CrGPDHs contains the conserved GSGAWA motif at residues 261-266 (CrGPDH1), 316-321 (CrGPDH2), and 267-272 (CrGPDH3), three-dimensional structures by homology modeling, based on the Homo sapiens GPD1 crystal structure, overview Chlamydomonas reinhardtii

Synonyms

EC Number Synonyms Comment Organism
1.1.1.8 glycerol-3-phosphate dehydrogenase
-
 Chlamydomonas reinhardtii
1.1.1.8 GPDH
-
 Chlamydomonas reinhardtii
1.1.1.8 NAD+-GPDH
-
 Chlamydomonas reinhardtii

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.8 NAD+
-
 Chlamydomonas reinhardtii
1.1.1.8 NADH
-
 Chlamydomonas reinhardtii