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Literature summary extracted from

  • Gallier, F.; Alexandre, J.A.; El Amri, C.; Deville-Bonne, D.; Peyrottes, S.; Perigaud, C.
    5,6-nucleoside phosphonate analogues architecture: synthesis and comparative evaluation towards metabolic enzymes (2011), ChemMedChem, 6, 1094-1106.
    View publication on PubMed

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.7.4.4 0.08
-
 dAMP isoform AMPK2, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C Homo sapiens
2.7.4.4 0.14
-
 dAMP isoform AMPK1, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.4 Homo sapiens
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.4 ATP + dAMP 100% activity Homo sapiens ADP + dADP
-
 ?
2.7.4.4 additional information the enzyme shows almost no activity towards tenofovir and adefovir Homo sapiens ?
-
 ?

Synonyms

EC Number Synonyms Comment Organism
2.7.4.4 AMPK1 isoform Homo sapiens
2.7.4.4 AMPK2 isoform Homo sapiens
2.7.4.4 NMP kinase
-
 Homo sapiens
2.7.4.4 nucleoside monophosphate kinase
-
 Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.7.4.4 80
-
 dAMP isoform AMPK2, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C Homo sapiens
2.7.4.4 500
-
 dAMP isoform AMPK1, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C Homo sapiens

kcat/KM [mM/s]

EC Number kcat/KM Value [1/mMs-1] kcat/KM Value Maximum [1/mMs-1] Substrate Comment Organism Structure
2.7.4.4 1000
-
 dAMP isoform AMPK2, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C Homo sapiens
2.7.4.4 3000
-
 dAMP isoform AMPK1, in 50 mM Tris/HCl (pH 7.4), 50 mM KCl, 5 mM MgCl2, at 37°C Homo sapiens