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Literature summary extracted from

  • Grundmann, A.; Kuznetsova, T.; Afiyatullov, S.Sh.; Li, S.M.
    FtmPT2, an N-prenyltransferase from Aspergillus fumigatus, catalyses the last step in the biosynthesis of fumitremorgin B (2008), ChemBioChem, 9, 2059-2063.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.5.1.110 expression in Saccharomyces cerevisiae Aspergillus fumigatus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.5.1.110 0.096
-
12alpha,13alpha-dihydroxyfumitremorgin C 37°C, pH not specified in the publication Aspergillus fumigatus
2.5.1.110 0.186
-
dimethylallyl diphosphate 37°C, pH not specified in the publication Aspergillus fumigatus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.110 additional information product formation is independent of the presence of metal ions. Even in the presence of EDTA no loss of enzyme activity is not detected Aspergillus fumigatus

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.5.1.110 50100
-
2 * 50100, SDS-PAGE Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.5.1.110 dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C Aspergillus fumigatus the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen diphosphate + fumitremorgin B
-
?

Organism

EC Number Organism UniProt Comment Textmining
2.5.1.110 Aspergillus fumigatus B9WZX7
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.5.1.110
-
Aspergillus fumigatus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.5.1.110 dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen Aspergillus fumigatus diphosphate + fumitremorgin B
-
?
2.5.1.110 dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C the enzyme is specific for dimethylallyl diphosphate as prenyl donor, no activity with geranyl diphosphate. Relatively high specificity towards the aromatic substrate, it is extremely regiospecific Aspergillus fumigatus diphosphate + fumitremorgin B
-
?
2.5.1.110 dimethylallyl diphosphate + fumitremorgin C relative activity of 10% compared to 12,13-dihydroxyfumitremorgin C Aspergillus fumigatus ?
-
?
2.5.1.110 additional information no activity with brevianamide F, tryprostatin A or B Aspergillus fumigatus ?
-
?

Subunits

EC Number Subunits Comment Organism
2.5.1.110 homodimer 2 * 50100, SDS-PAGE Aspergillus fumigatus

Synonyms

EC Number Synonyms Comment Organism
2.5.1.110 ftmH
-
Aspergillus fumigatus
2.5.1.110 FtmPT2
-
Aspergillus fumigatus

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
2.5.1.110 37
-
assay at Aspergillus fumigatus

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.5.1.110 0.03
-
dimethylallyl diphosphate 37°C, pH not specified in the publication Aspergillus fumigatus
2.5.1.110 0.03
-
12alpha,13alpha-dihydroxyfumitremorgin C 37°C, pH not specified in the publication Aspergillus fumigatus