EC Number | Cloned (Comment) | Organism |
---|---|---|
2.5.1.110 | expression in Saccharomyces cerevisiae | Aspergillus fumigatus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.110 | 0.096 | - |
12alpha,13alpha-dihydroxyfumitremorgin C | 37°C, pH not specified in the publication | Aspergillus fumigatus | |
2.5.1.110 | 0.186 | - |
dimethylallyl diphosphate | 37°C, pH not specified in the publication | Aspergillus fumigatus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.110 | additional information | product formation is independent of the presence of metal ions. Even in the presence of EDTA no loss of enzyme activity is not detected | Aspergillus fumigatus |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
2.5.1.110 | 50100 | - |
2 * 50100, SDS-PAGE | Aspergillus fumigatus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.110 | dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C | Aspergillus fumigatus | the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen | diphosphate + fumitremorgin B | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.110 | Aspergillus fumigatus | B9WZX7 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.5.1.110 | - |
Aspergillus fumigatus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.110 | dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C | the enzyme is involved in the biosynthetic pathways of several indole alkaloids such as fumitremorgins and verruculogen | Aspergillus fumigatus | diphosphate + fumitremorgin B | - |
? | |
2.5.1.110 | dimethylallyl diphosphate + 12alpha,13alpha-dihydroxyfumitremorgin C | the enzyme is specific for dimethylallyl diphosphate as prenyl donor, no activity with geranyl diphosphate. Relatively high specificity towards the aromatic substrate, it is extremely regiospecific | Aspergillus fumigatus | diphosphate + fumitremorgin B | - |
? | |
2.5.1.110 | dimethylallyl diphosphate + fumitremorgin C | relative activity of 10% compared to 12,13-dihydroxyfumitremorgin C | Aspergillus fumigatus | ? | - |
? | |
2.5.1.110 | additional information | no activity with brevianamide F, tryprostatin A or B | Aspergillus fumigatus | ? | - |
? |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
2.5.1.110 | homodimer | 2 * 50100, SDS-PAGE | Aspergillus fumigatus |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.110 | ftmH | - |
Aspergillus fumigatus |
2.5.1.110 | FtmPT2 | - |
Aspergillus fumigatus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
2.5.1.110 | 37 | - |
assay at | Aspergillus fumigatus |
EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.110 | 0.03 | - |
dimethylallyl diphosphate | 37°C, pH not specified in the publication | Aspergillus fumigatus | |
2.5.1.110 | 0.03 | - |
12alpha,13alpha-dihydroxyfumitremorgin C | 37°C, pH not specified in the publication | Aspergillus fumigatus |