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Literature summary extracted from
- Gene disruption and biochemical characterization of verruculogen synthase of Aspergillus fumigatus (2011), ChemBioChem, 12, 711-714.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.14.11.38 | ascorbate | not essential but involved in the FtmF reaction | Aspergillus fumigatus |  |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.14.11.38 | expressed in Escherichia coli as a His6-tagged fusion protein | Aspergillus fumigatus |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.38 | 0.003 | - |
2-oxoglutarate | pH 6.0, 30°C | Aspergillus fumigatus | |
| 1.14.11.38 | 0.021 | - |
fumitremorgin B | pH 6.0, 30°C | Aspergillus fumigatus | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.38 | 77000 | - |
gel filtration | Aspergillus fumigatus |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.14.11.38 | Aspergillus fumigatus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.14.11.38 | - |
Aspergillus fumigatus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.14.11.38 | fumitremorgin B + 2-oxoglutarate + 2 O2 + AH2 | - |
Aspergillus fumigatus | verruculogen + succinate + CO2 + H2O + A | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 1.14.11.38 | FtmF | - |
Aspergillus fumigatus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.38 | 37 | - |
10 min, 10% loss of activity | Aspergillus fumigatus |
Turnover Number [1/s]
| EC Number | Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.14.11.38 | 0.19 | - |
fumitremorgin B | pH 6.0, 30°C | Aspergillus fumigatus | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.14.11.38 | 6 | - |
- |
Aspergillus fumigatus |
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Release 2023.1 (January 2023)
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