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Literature summary extracted from

  • Kato, N.; Suzuki, H.; Takagi, H.; Asami, Y.; Kakeya, H.; Uramoto, M.; Usui, T.; Takahashi, S.; Sugimoto, Y.; Osada, H.
    Identification of cytochrome P450s required for fumitremorgin biosynthesis in Aspergillus fumigatus (2009), ChemBioChem, 10, 920-928.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.14.14.118 expressed in Saccharomyces cerevisiae strain YPH500 Aspergillus fumigatus
1.14.14.119 expressed in Saccharomyces cerevisiae Aspergillus fumigatus
1.14.19.71 expressed in Saccharomyces cerevisiae Aspergillus fumigatus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.118 tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus fumigatus
-
 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.118 tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus fumigatus BM939
-
 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.119 fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 Aspergillus fumigatus the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.14.119 fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 Aspergillus fumigatus BM939 the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.19.71 tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus fumigatus
-
 fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.71 tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus fumigatus BM939
-
 fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.118 Aspergillus fumigatus B9WZX1
-
-
1.14.14.118 Aspergillus fumigatus BM939 B9WZX1
-
-
1.14.14.119 Aspergillus fumigatus B9WZX6
-
-
1.14.14.119 Aspergillus fumigatus BM939 B9WZX6
-
-
1.14.19.71 Aspergillus fumigatus B9WZX4
-
-
1.14.19.71 Aspergillus fumigatus BM939 B9WZX4
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.118 tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus fumigatus 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.118 tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus fumigatus BM939 6-hydroxytryprostatin B + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.119 fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
-
 Aspergillus fumigatus 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.14.119 fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen Aspergillus fumigatus 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.14.119 fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2
-
 Aspergillus fumigatus BM939 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.14.119 fumitremorgin C + 2 [reduced NADPH-hemoprotein reductase] + 2 O2 the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen Aspergillus fumigatus BM939 12alpha,13alpha-dihydroxyfumitremorgin C + 2 [oxidized NADPH-hemoprotein reductase] + 2 H2O
-
 ?
1.14.19.71 additional information the enzyme preferably dephosphorylates disaccharides containing an O-aglycosyl linkage Aspergillus fumigatus ?
-
 ?
1.14.19.71 additional information the enzyme preferably dephosphorylates disaccharides containing an O-aglycosyl linkage Aspergillus fumigatus BM939 ?
-
 ?
1.14.19.71 tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus fumigatus fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.71 tryprostatin A + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus fumigatus BM939 fumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.71 tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus fumigatus demethoxyfumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.19.71 tryprostatin B + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus fumigatus BM939 demethoxyfumitremorgin C + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.14.118 ftmC
-
 Aspergillus fumigatus
1.14.14.118 FtmC protein
-
 Aspergillus fumigatus
1.14.14.119 ftmG
-
 Aspergillus fumigatus
1.14.19.71 ftmE
-
 Aspergillus fumigatus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.119 heme heme-thiolate protein (P-450) Aspergillus fumigatus
1.14.19.71 heme heme-thiolate protein (P-450) Aspergillus fumigatus

General Information

EC Number General Information Comment Organism
1.14.14.118 malfunction disruption of the ftmC gene leads to substantial accumulation of tryprostatin B and its cyclization product demethoxyfumitremorgin C Aspergillus fumigatus
1.14.14.119 malfunction the disruption of ftmG results in the loss of production of 12alpha,13alpha-dihydroxyfumitremorgin C and fumitremorgin B Aspergillus fumigatus
1.14.14.119 physiological function the enzyme is involved in the biosynthetic pathway of the indole alkaloid verruculogen Aspergillus fumigatus
1.14.19.71 physiological function the enzyme is involved in the biosynthetic pathway of several indole alkaloids such as fumitremorgins and verruculogen Aspergillus fumigatus