EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
3.1.1.1 | R43S | the mutant enzyme shows enhanced sensitivity toward some organophosphorus compounds. The IC50 of the mutant enzyme to dichlorvos is lower than that of the wild type AFEST by a factor of 1.56 | Archaeoglobus fulgidus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
3.1.1.1 | chlorpyrifos | - |
Archaeoglobus fulgidus | |
3.1.1.1 | diazinon | - |
Archaeoglobus fulgidus | |
3.1.1.1 | dichlorvos | Arg43 plays an important role in the interaction between AFEST and dichlorvos by means of stabilizing the complex. The IC50 of the mutant enzyme R43S to dichlorvos is lower than that of the wild type AFEST by a factor of 1.56 | Archaeoglobus fulgidus | |
3.1.1.1 | paraoxon | - |
Archaeoglobus fulgidus | |
3.1.1.1 | triazophos | - |
Archaeoglobus fulgidus |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
3.1.1.1 | Archaeoglobus fulgidus | O28558 | - |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
3.1.1.1 | 4-nitrophenyl butyrate + H2O | - |
Archaeoglobus fulgidus | 4-nitrophenol + butyrate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
3.1.1.1 | AFEST | - |
Archaeoglobus fulgidus |
EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|---|
3.1.1.1 | 50 | - |
assay at | Archaeoglobus fulgidus |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
3.1.1.1 | 7.1 | - |
assay at | Archaeoglobus fulgidus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
3.1.1.1 | 0.25 | - |
triazophos | pH 7.1, 50°C | Archaeoglobus fulgidus | |
3.1.1.1 | 0.36 | - |
chlorpyrifos | pH 7.1, 50°C | Archaeoglobus fulgidus | |
3.1.1.1 | 0.57 | - |
diazinon | pH 7.1, 50°C | Archaeoglobus fulgidus | |
3.1.1.1 | 1.2 | - |
dichlorvos | pH 7.1, 50°C | Archaeoglobus fulgidus | |
3.1.1.1 | 1.29 | - |
paraoxon | pH 7.1, 50°C | Archaeoglobus fulgidus |