EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.33 | cholesterol | about 125% activity at 0.1 mM | Homo sapiens | |
2.7.1.33 | glyburide | - |
Homo sapiens | |
2.7.1.33 | glyburide | isoform PanK1b is activated by glyburide | Homo sapiens | |
2.7.1.33 | additional information | isoform PanK3 is not activated by 1,4-naphthoquinone and phenylmercuric acid | Homo sapiens | |
2.7.1.33 | O-oleoylcarnitine | 140% activation at 0.1 mM | Homo sapiens | |
2.7.1.33 | O-palmitoylcarnitine | 120% activation at 0.1 mM | Homo sapiens | |
2.7.1.33 | oleoylethanolamide | 120% activation at 0.1 mM | Homo sapiens | |
2.7.1.33 | tamoxifen | 140% activation at 0.1 mM | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.7.1.33 | A267F | catalytically inactive | Homo sapiens |
2.7.1.33 | A269F | catalytically inactive | Homo sapiens |
2.7.1.33 | R207A | catalytically inactive | Homo sapiens |
2.7.1.33 | S195V | the mutant is insensitive to acetyl-CoA and has a KM defect for pantothenate | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.33 | 1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide | - |
Homo sapiens | |
2.7.1.33 | acetyl-CoA | complete inhibition of isoform PanK3 at 0.008 mM | Homo sapiens | |
2.7.1.33 | ADP | competitive inhibitor of isoform PanK3 with respect to ATP1 and a mixed-type inhibitor with respect to pantothenate | Homo sapiens | |
2.7.1.33 | chloranil | - |
Homo sapiens | |
2.7.1.33 | dehydroisoandrosterone | about 30% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
2.7.1.33 | Dehydroisoandrosterone sulfate | about 8% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
2.7.1.33 | ephedrine hydrochloride | - |
Homo sapiens | |
2.7.1.33 | estradiol | about 80% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
2.7.1.33 | Estradiol sulfate | about 90% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
2.7.1.33 | Estrone sulfate | about 50% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
2.7.1.33 | Fusidic acid | - |
Homo sapiens | |
2.7.1.33 | glipizide | - |
Homo sapiens | |
2.7.1.33 | glyburide | - |
Homo sapiens | |
2.7.1.33 | GW5074 | - |
Homo sapiens | |
2.7.1.33 | Hexachlorophene | - |
Homo sapiens | |
2.7.1.33 | MCC-555 | MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b; MCC-555 inhibits all three isoforms with a rank order of PanK3 > PanK2 > PanK1b | Homo sapiens | |
2.7.1.33 | additional information | isoform PanK3 is not inhibited by estrone | Homo sapiens | |
2.7.1.33 | pioglitazone hydrochloride | - |
Homo sapiens | |
2.7.1.33 | pregnenolone sulfate | about 10% residual activity at 0.1 mM (isoform PanK3); about 92% residual activity at 0.1 mM (isoform PanK3) | Homo sapiens | |
2.7.1.33 | Psi-rhodomyrtoxin | - |
Homo sapiens | |
2.7.1.33 | Reactive blue 2 | - |
Homo sapiens | |
2.7.1.33 | Ro 41-0960 | - |
Homo sapiens | |
2.7.1.33 | rosiglitazone | - |
Homo sapiens | |
2.7.1.33 | tamoxifen | - |
Homo sapiens | |
2.7.1.33 | tolfenamic acid | - |
Homo sapiens | |
2.7.1.33 | tyrphostin AG 528 | - |
Homo sapiens | |
2.7.1.33 | tyrphostin AG 808 | - |
Homo sapiens | |
2.7.1.33 | WIN 62577 | - |
Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.7.1.33 | 0.014 | - |
(R)-pantothenate | isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | |
2.7.1.33 | 0.311 | - |
ATP | isoform PanK3, at pH 7.5 and 37°C | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.33 | Homo sapiens | - |
- |
- |
2.7.1.33 | Homo sapiens | Q9H999 | isoform PanK3 | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.7.1.33 | HepG2/C3A cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.33 | ATP + (R)-pantothenate | - |
Homo sapiens | ADP + (R)-4'-phosphopantothenate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.33 | PanK1b | isoform | Homo sapiens |
2.7.1.33 | PanK2 | isoform | Homo sapiens |
2.7.1.33 | PanK3 | isoform | Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.1.33 | 0.0001 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Fusidic acid | |
2.7.1.33 | 0.0004 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | 1,4-phenylene-bis(1,2-ethanediyl)bis-isothiourea dihydrobromide | |
2.7.1.33 | 0.0007 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | WIN 62577 | |
2.7.1.33 | 0.001 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | pioglitazone hydrochloride | |
2.7.1.33 | 0.0013 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Reactive blue 2 | |
2.7.1.33 | 0.0016 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | ephedrine hydrochloride | |
2.7.1.33 | 0.0016 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Psi-rhodomyrtoxin | |
2.7.1.33 | 0.0017 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | rosiglitazone | |
2.7.1.33 | 0.0025 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | pregnenolone sulfate | |
2.7.1.33 | 0.003 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | tyrphostin AG 528 | |
2.7.1.33 | 0.0035 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Dehydroisoandrosterone sulfate | |
2.7.1.33 | 0.0039 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Ro 41-0960 | |
2.7.1.33 | 0.0052 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | glipizide | |
2.7.1.33 | 0.0059 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | chloranil | |
2.7.1.33 | 0.0068 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | glyburide | |
2.7.1.33 | 0.0088 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | Hexachlorophene | |
2.7.1.33 | 0.009 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | tyrphostin AG 808 | |
2.7.1.33 | 0.0092 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | GW5074 | |
2.7.1.33 | 0.0092 | - |
isoform PanK3, at pH 7.5 and 37°C | Homo sapiens | tolfenamic acid |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.7.1.33 | metabolism | pantothenate kinase catalyzes the rate-controlling step in coenzyme A biosynthesis | Homo sapiens |