Literature summary extracted from

Duan, G.; Saint, R.B.; Helliwell, C.A.; Behm, C.A.; Wang, M.B.; Waterhouse, P.M.; Gordon, K.H.
C. elegans RNA-dependent RNA polymerases rrf-1 and ego-1 silence Drosophila transgenes by differing mechanisms (2013), Cell. Mol. Life Sci., 70, 1469-1481.

Organism

EC Number	Organism	UniProt	Comment	Textmining
2.7.7.48	Caenorhabditis elegans	G5EBQ3	isoform ego-1	-
2.7.7.48	Caenorhabditis elegans	G5ECM1	isoform rrf-1	-

Synonyms

EC Number	Synonyms	Comment	Organism
2.7.7.48	ego-11	-	Caenorhabditis elegans
2.7.7.48	rrf-1	-	Caenorhabditis elegans

General Information

EC Number	General Information	Comment	Organism
2.7.7.48	physiological function	expression in Drosophila melanogaster enhances transitive dsRNA-dependent silencing	Caenorhabditis elegans
2.7.7.48	physiological function	expression in Drosophila melanogaster triggers transcriptional silencing of unpaired DNA during embryonic mitosis. Isoform ego-1 triggers dsRNA-independent silencing, specifically of transgenes. The strain w, da-Gal4, UAST-ego-1, constitutively expressing ego-1, is capable of silencing transgene including dsRNA hairpin upon a single cross	Caenorhabditis elegans

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Release 2023.1 (January 2023)