EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.5.1.46 | N1-guanyl-1,7-diaminoheptane | i.e. GC7 | Mus musculus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
2.5.1.46 | endoplasmic reticulum | - |
Mus musculus | 5783 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | Mus musculus | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | Mus musculus C57/BL6J | - |
[eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.5.1.46 | Mus musculus | - |
- |
- |
2.5.1.46 | Mus musculus C57/BL6J | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.5.1.46 | fibroblast | - |
Mus musculus | - |
2.5.1.46 | liver | - |
Mus musculus | - |
2.5.1.46 | MEF cell | - |
Mus musculus | - |
2.5.1.46 | pancreatic beta cell | - |
Mus musculus | - |
2.5.1.46 | pancreatic islet | beta-islet cell | Mus musculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | - |
Mus musculus | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? | |
2.5.1.46 | [eIF5A-precursor]-lysine + spermidine | - |
Mus musculus C57/BL6J | [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.5.1.46 | DHS | - |
Mus musculus |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
2.5.1.46 | 0.01 | - |
N1-guanyl-1,7-diaminoheptane | pH and temperature not specified in the publication | Mus musculus |
EC Number | General Information | Comment | Organism |
---|---|---|---|
2.5.1.46 | malfunction | deoxyhypusine synthase haploinsufficiency attenuates acute cytokine signaling, overview. DHS dysfunction in the setting of diabetes mellitus, overview | Mus musculus |
2.5.1.46 | additional information | Dhps heterozygosity does not lead to significant inhibition of proliferation or cell cycle progression, Dhps heterozygosity does not alter growth or metabolic homeostasis, overview | Mus musculus |
2.5.1.46 | physiological function | deoxyhypusine synthase, DHS, catalyzes the post-translational formation of the amino acid hypusine. Hypusine is unique to the eukaryotic translational initiation factor 5A (eIF5A), and is required for its functions in mRNA shuttling, translational elongation and stress granule formation. DHS promotes cytokine and ER stress signaling in the islet beta cell and thereby contributes to its dysfunction in the setting of diabetes mellitus | Mus musculus |