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Literature summary extracted from

  • Fischer, S.; Filipek-Gorniok, B.; Ledin, J.
    Zebrafish Ext2 is necessary for Fgf and Wnt signaling, but not for Hh signaling (2011), BMC Dev. Biol., 11, 53.
    View publication on PubMedView publication on EuropePMC

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.224 Danio rerio
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 gene ext2
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2.4.1.225 Danio rerio
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 gene ext2
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Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.224 additional information zebrafish ext2 gene is ubiquitously expressed during zebrafish development Danio rerio
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2.4.1.225 additional information zebrafish ext2 gene is ubiquitously expressed during zebrafish development Danio rerio
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Synonyms

EC Number Synonyms Comment Organism
2.4.1.224 EXT2
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 Danio rerio
2.4.1.225 EXT2
-
 Danio rerio

General Information

EC Number General Information Comment Organism
2.4.1.224 malfunction Fgf targeted gene expression is reduced in ext2 mutants and the remaining expression is readily inhibited by SU5402, an FGF receptor inhibitor. In the ext2 mutants, Fgf signaling is affected during nervous system development, mechanism, overview, and reduction of Fgf ligands in the mutants affects tail development. Wnt signaling is also affected in the ext2 mutants, while Hh dependent signaling is apparently unaffected in the ext2 mutants, Hh targeted gene expression is not reduced, the Hh inhibitor cyclopamine is not more affective in the mutants and Hh-dependent cell differentiation in the retina and in the myotome are normal in ext2 mutants, ext2 mutant phenotypes, overview Danio rerio
2.4.1.224 physiological function Ext1 and Ext2 together form a copolymerase which is responsible for the polymerization process where repeating units of N-acetylglucosamine and glucuronic acid are incorporated in the growing linear polysaccharide chain, see also EC 2.4.1.225. Gene ext2 is involved in Fgf and Wnt signaling but not in Hh signaling, ext2 is a general enhancer of Fgf target gene expression, ext2 interacts genetically with Fgf signaling during tail development, specificity for gene ext2 in signaling pathways during embryonic development, overview Danio rerio
2.4.1.225 malfunction Fgf targeted gene expression is reduced in ext2 mutants and the remaining expression is readily inhibited by SU5402, an FGF receptor inhibitor. In the ext2 mutants, Fgf signaling is affected during nervous system development, mechanism, overview, and reduction of Fgf ligands in the mutants affects tail development. Wnt signaling is also affected in the ext2 mutants, while Hh dependent signaling is apparently unaffected in the ext2 mutants, Hh targeted gene expression is not reduced, the Hh inhibitor cyclopamine is not more affective in the mutants and Hh-dependent cell differentiation in the retina and in the myotome are normal in ext2 mutants, ext2 mutant phenotypes, overview Danio rerio
2.4.1.225 physiological function Ext1 and Ext2 together form a copolymerase which is responsible for the polymerization process where repeating units of N-acetylglucosamine and glucuronic acid are incorporated in the growing linear polysaccharide chain, see also EC 2.4.1.224. Gene ext2 is involved in Fgf and Wnt signaling but not in Hh signaling, ext2 is a general enhancer of Fgf target gene expression, ext2 interacts genetically with Fgf signaling during tail development, specificity for gene ext2 in signaling pathways during embryonic development, overview Danio rerio