EC Number | Cloned (Comment) | Organism |
---|---|---|
2.4.2.12 | expressed in Escherichia coli Rosetta 2 (DE3) | Homo sapiens |
EC Number | Protein Variants | Comment | Organism |
---|---|---|---|
2.4.2.12 | DELTA D93 | naturally occuring mutation in CHS-828 or APO866 resistant cell lines, about 20% of wild type aczivity | Homo sapiens |
2.4.2.12 | H191R | activity reduced by about 50% | Homo sapiens |
2.4.2.12 | H191R/K342R | naturally occuring mutation in APO866 resistant cell line | Homo sapiens |
2.4.2.12 | H191R/K342R/Q388R | naturally occuring mutation in TP201565 resistant cell line | Homo sapiens |
2.4.2.12 | K342R | naturally occuring mutation, activity reduced by about 50% | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.4.2.12 | CHS-828 | competitive inhibitor | Homo sapiens | |
2.4.2.12 | FK-866 | - |
Homo sapiens | |
2.4.2.12 | TP201565 | competitive inhibitor | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.4.2.12 | Homo sapiens | P43490 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.4.2.12 | immobilized metal ion affinity chromatography (Ni2+) | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
2.4.2.12 | HCT-116 cell | - |
Homo sapiens | - |
2.4.2.12 | HEK-293T cell | - |
Homo sapiens | - |
2.4.2.12 | NYH cell | - |
Homo sapiens | - |
2.4.2.12 | PC-3 cell | - |
Homo sapiens | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.4.2.12 | nicotinamide + 5-phosphoribosyl 1-diphosphate | - |
Homo sapiens | nicotinamide mononucleotide + diphosphate | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.4.2.12 | nicotinamide phosphoribosyltransferase | - |
Homo sapiens |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.4.2.12 | 0.00011 | - |
wild type protein, pH 8.5, 37°C | Homo sapiens | FK-866 | |
2.4.2.12 | 0.008585 | - |
H191R mutant protein, pH 8.5, 37°C | Homo sapiens | FK-866 |