EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
2.7.1.21 | 3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | - |
Ureaplasma parvum | |
2.7.1.21 | 3'-azido-3'-deoxythymidine | - |
Homo sapiens | |
2.7.1.21 | 3'-azido-3'-deoxythymidine | - |
Ureaplasma parvum |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
2.7.1.21 | Homo sapiens | P04183 | - |
- |
2.7.1.21 | Ureaplasma parvum | Q9PPP5 | - |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
2.7.1.21 | - |
Homo sapiens |
2.7.1.21 | - |
Ureaplasma parvum |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
2.7.1.21 | ATP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | 12.3% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | 2.4% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-(2-phenylethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine | 3.1% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine | 7.1% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine | 2.7% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine | 6.5% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-(3-chloropropyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | 13.7% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | 2.6% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 11.6% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 4.8% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 2.9% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 8.7% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 2.1% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 5.5% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 1.9% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 7.2% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 2.2% activity compared to thymidine | Homo sapiens | ADP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | 4.7% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-azido-3'-deoxythymidine | 27.8% activity compared to thymidine | Ureaplasma parvum | ADP + 3'-azido-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + 3'-azido-3'-deoxythymidine | 47.3% activity compared to thymidine | Homo sapiens | ADP + 3'-azido-3'-deoxythymidine 5'-phosphate | - |
? | |
2.7.1.21 | ATP + thymidine | 100% activity | Homo sapiens | ADP + dTMP | - |
? | |
2.7.1.21 | ATP + thymidine | 100% activity | Ureaplasma parvum | ADP + dTMP | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
2.7.1.21 | thymidine kinase 1 | - |
Homo sapiens |
2.7.1.21 | thymidine kinase 1 | - |
Ureaplasma parvum |
2.7.1.21 | TK1 | - |
Homo sapiens |
2.7.1.21 | TK1 | - |
Ureaplasma parvum |
EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|---|
2.7.1.21 | 0.003 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-azido-3'-deoxythymidine | |
2.7.1.21 | 0.0125 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-azido-3'-deoxythymidine | |
2.7.1.21 | 0.044 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.053 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.06 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.071 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-(4-fluorophenyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.073 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.078 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-benzyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.086 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.099 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.105 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.114 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.12 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-(2-phenyl-ethyl)-1,2,3-triazole-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.15 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-pentyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.189 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.2 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-phenyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.208 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-(3-chloro-propyl)-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.211 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-(2-pyridine)-1,2,3-triazole-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.311 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Homo sapiens | 3'-(4-propyl-1,2,3-triazol-1-yl)-3'-deoxythymidine | |
2.7.1.21 | 0.318 | - |
in 50 mM Tris/HCl pH 7.6, 5 mM MgCl2, at 37°C | Ureaplasma parvum | 3'-(4-tert-butyl-1,2,3-triazol-1-yl)-3'-deoxythymidine |