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Literature summary extracted from
- Flavonoids as receptor tyrosine kinase FLT3 inhibitors (2013), Bioorg. Med. Chem. Lett., 23, 1768-1770.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 2.7.10.1 | luteolin | luteolin is a potent receptor-type tyrosine-protein kinase FLT3 inhibitor. Luteolin suppresses cell proliferation in MV4,11 cells with constitutively activated FLT3 | Homo sapiens |  |
| 2.7.10.1 | MFCD09840836 | - |
Homo sapiens | |
| 2.7.10.1 | quercetin | - |
Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.10.1 | Homo sapiens | P36888 | receptor-type tyrosine-protein kinase FLT3 | - |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.10.1 | FLT3 | - |
Homo sapiens |
| 2.7.10.1 | receptor-type tyrosine-protein kinase FLT3 | - |
Homo sapiens |
IC50 Value
| EC Number | IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|---|
| 2.7.10.1 | 0.0000082 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | MFCD09840836 | |
| 2.7.10.1 | 0.00059 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | quercetin | |
| 2.7.10.1 | 0.00083 | - |
pH not specified in the publication, temperature not specified in the publication | Homo sapiens | luteolin | |
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