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Literature summary extracted from

  • Agarwal, H.K.; Buckheit, K.W.; Buckheit, R.W.; Parang, K.
    Synthesis and anti-HIV activities of symmetrical dicarboxylate esters of dinucleoside reverse transcriptase inhibitors (2012), Bioorg. Med. Chem. Lett., 22, 5451-5454.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.7.49 (R)-9-(2-phosphonomethoxypropyl)adenine
-
Human immunodeficiency virus 1
2.7.7.49 1,10-di-2',3'-dideoxy-3'-thiacytidine-decanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,10-di-3'-azido-2',3'-dideoxythymidine-decanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,10-di-3'-fluoro-2',3'-dideoxythymidine-decanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,12-di-2',3'-dideoxy-3'-thiacytidine-dodecanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,12-di-3'-azido-2',3'-dideoxythymidine-dodecanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,12-di-3'-fluoro-2',3'-dideoxythymidine-dodecanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,14-di-2',3'-dideoxy-3'-thiacytidine-tetradecanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,14-di-3'-azido-2',3'-dideoxythymidine-tetradecanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,14-di-3'-fluoro-2',3'-dideoxythymidine-tetradecanoate
-
Human immunodeficiency virus 1
2.7.7.49 1,4-di-2',3'-dideoxy-3'-thiacytidine-succinate
-
Human immunodeficiency virus 1
2.7.7.49 2',3'-didehydro-2',3'-dideoxythymidine
-
Human immunodeficiency virus 1
2.7.7.49 2',3'-dideoxy-3'-thiacytidine
-
Human immunodeficiency virus 1
2.7.7.49 2',3'-dideoxy-5-fluoro-3'-thiacytidine
-
Human immunodeficiency virus 1
2.7.7.49 2',3'-dideoxycytidine
-
Human immunodeficiency virus 1
2.7.7.49 3'-azido-2',3'-dideoxythymidine
-
Human immunodeficiency virus 1
2.7.7.49 3'-azido-3'-deoxythymidine
-
Human immunodeficiency virus 1
2.7.7.49 3'-fluoro-2',3'-dideoxythymidine
-
Human immunodeficiency virus 1
2.7.7.49 additional information inhibitor structure-activity relationships, overview Human immunodeficiency virus 1

Organism

EC Number Organism UniProt Comment Textmining
2.7.7.49 Human immunodeficiency virus 1
-
-
-

IC50 Value

EC Number IC50 Value IC50 Value Maximum Comment Organism Inhibitor Structure
2.7.7.49 0.00000076
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,14-di-3'-fluoro-2',3'-dideoxythymidine-tetradecanoate
2.7.7.49 0.00000097
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,12-di-3'-fluoro-2',3'-dideoxythymidine-dodecanoate
2.7.7.49 0.000001
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,10-di-3'-fluoro-2',3'-dideoxythymidine-decanoate
2.7.7.49 0.000002
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 3'-azido-2',3'-dideoxythymidine
2.7.7.49 0.000002
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 3'-fluoro-2',3'-dideoxythymidine
2.7.7.49 0.000002
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,12-di-3'-azido-2',3'-dideoxythymidine-dodecanoate
2.7.7.49 0.000003
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,14-di-3'-fluoro-2',3'-dideoxythymidine-tetradecanoate
2.7.7.49 0.000003
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,14-di-3'-azido-2',3'-dideoxythymidine-tetradecanoate
2.7.7.49 0.000003
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,14-di-2',3'-dideoxy-3'-thiacytidine-tetradecanoate
2.7.7.49 0.000003
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,14-di-3'-azido-2',3'-dideoxythymidine-tetradecanoate
2.7.7.49 0.000004
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,10-di-3'-fluoro-2',3'-dideoxythymidine-decanoate
2.7.7.49 0.000004
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,12-di-3'-fluoro-2',3'-dideoxythymidine-dodecanoate
2.7.7.49 0.000004
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,12-di-3'-azido-2',3'-dideoxythymidine-dodecanoate
2.7.7.49 0.000004
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,10-di-3'-azido-2',3'-dideoxythymidine-decanoate
2.7.7.49 0.000005
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,10-di-3'-azido-2',3'-dideoxythymidine-decanoate
2.7.7.49 0.000008
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 3'-azido-2',3'-dideoxythymidine
2.7.7.49 0.000009
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,12-di-2',3'-dideoxy-3'-thiacytidine-dodecanoate
2.7.7.49 0.00002
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 3'-fluoro-2',3'-dideoxythymidine
2.7.7.49 0.00002
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,12-di-2',3'-dideoxy-3'-thiacytidine-dodecanoate
2.7.7.49 0.00003
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,10-di-2',3'-dideoxy-3'-thiacytidine-decanoate
2.7.7.49 0.00003
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,14-di-2',3'-dideoxy-3'-thiacytidine-tetradecanoate
2.7.7.49 0.00006
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,10-di-2',3'-dideoxy-3'-thiacytidine-decanoate
2.7.7.49 0.00009
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 2',3'-dideoxy-3'-thiacytidine
2.7.7.49 0.00013
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,4-di-2',3'-dideoxy-3'-thiacytidine-succinate
2.7.7.49 0.00015
-
enzyme from HIV-1 US/92/727, pH and temperature not specified in the publication Human immunodeficiency virus 1 1,4-di-2',3'-dideoxy-3'-thiacytidine-succinate
2.7.7.49 0.0002
-
enzyme from HIV-1 III B, pH and temperature not specified in the publication Human immunodeficiency virus 1 2',3'-dideoxy-3'-thiacytidine