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Literature summary extracted from
- The substrate binding preferences of Plasmodium thymidylate kinase (2011), Biol. Pharm. Bull., 34, 173-176.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 2.7.4.9 | expressed in Escherichia coli | Plasmodium falciparum |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 2.7.4.9 | Plasmodium falciparum | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 2.7.4.9 | TALON metal affinity resin column chromatography | Plasmodium falciparum |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 2.7.4.9 | ATP + dGMP | dGMP is unable to displace TMP from its binding site | Plasmodium falciparum | ADP + dGDP | - |
r |  |
| 2.7.4.9 | ATP + TMP | TMP is able to partially displace dGMP from the binding site | Plasmodium falciparum | ADP + TDP | - |
r | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 2.7.4.9 | ATP: TMP phosphotransferase | - |
Plasmodium falciparum |
| 2.7.4.9 | deoxythymidine monophosphate kinase | - |
Plasmodium falciparum |
| 2.7.4.9 | dTMP kinase | - |
Plasmodium falciparum |
| 2.7.4.9 | thymidylate kinase | - |
Plasmodium falciparum |
| 2.7.4.9 | TMPK | - |
Plasmodium falciparum |
General Information
| EC Number | General Information | Comment | Organism |
|---|---|---|---|
| 2.7.4.9 | physiological function | thymidylate kinase is a key enzyme in the control of nucleotide metabolism and synthesis of DNA | Plasmodium falciparum |
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