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Literature summary extracted from

  • Koetzler, M.P.; Blank, S.; Bantleon, F.I.; Spillner, E.; Meyer, B.
    Donor substrate binding and enzymatic mechanism of human core alpha1,6-fucosyltransferase (FUT8) (2012), Biochim. Biophys. Acta, 1820, 1915-1925.
    View publication on PubMed

Application

EC Number Application Comment Organism
2.4.1.68 medicine the enzymatic product of core alpha1,6-fucosyltransferase plays a major role in a plethora of pathological conditions, e.g. in prognosis of hepatocellular carcinoma and in colon cancer Homo sapiens

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.4.1.68 expressed in Sf9 insect cells as soluble enzyme lacking the transmembrane region Homo sapiens

Crystallization (Commentary)

EC Number Crystallization (Comment) Organism
2.4.1.68 co-crystallized with GDP-L-fucose Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.4.1.68 GDP strong inhibitor Homo sapiens
2.4.1.68 GMP weak inhibitor Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.4.1.68 0.012
-
N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine pH and temperature not specified in the publication Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
2.4.1.68 membrane a transmembrane protein Homo sapiens 16020
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.4.1.68 62000
-
1 * 62000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.4.1.68 Homo sapiens Q9BYC5
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.4.1.68 HEK-293 cell
-
Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.4.1.68 GDP-L-fucose + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine
-
Homo sapiens GDP + N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-[alpha-L-fucosyl-(1-6)]-N-acetyl-beta-D-glucosaminyl]asparagine
-
ir

Subunits

EC Number Subunits Comment Organism
2.4.1.68 monomer 1 * 62000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.4.1.68 alpha1,6-fucosyltransferase
-
Homo sapiens
2.4.1.68 alpha1-6FucT
-
Homo sapiens
2.4.1.68 FUT8
-
Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
2.4.1.68 0.45
-
N4-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-3)-[N-acetyl-beta-D-glucosaminyl-(1-2)-alpha-D-mannosyl-(1-6)]-beta-D-mannosyl-(1-4)-N-acetyl-beta-D-glucosaminyl-(1-4)-N-acetyl-beta-D-glucosaminyl]asparagine pH and temperature not specified in the publication Homo sapiens

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
2.4.1.68 0.0036
-
GDP pH and temperature not specified in the publication Homo sapiens
2.4.1.68 2.8
-
GMP pH and temperature not specified in the publication Homo sapiens