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Literature summary extracted from

  • Boonsri, P.; Neumann, T.S.; Olson, A.L.; Cai, S.; Herdendorf, T.J.; Miziorko, H.M.; Hannongbua, S.; Sem, D.S.
    Molecular docking and NMR binding studies to identify novel inhibitors of human phosphomevalonate kinase (2013), Biochem. Biophys. Res. Commun., 430, 313-319.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
2.7.4.2 expressed in Escherichia coli BL21 (DE3) Rosetta cells Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.7.4.2 2,2',2''-(biphenyl-2,4,6-triyltrisulfanediyl)triacetate
-
 Homo sapiens
2.7.4.2 2,2'-[(5,8-dihydroxy-9,10-dioxo-4a,9,9a,10-tetrahydroanthracene-1,4-diyl)diimino]bis(5-methylbenzenesulfonate)
-
 Homo sapiens
2.7.4.2 4-[(E)-(2,4-dihydroxyphenyl)diazenyl]-5-methylnaphthalene-2,7-disulfonate
-
 Homo sapiens
2.7.4.2 luteolin
-
 Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
2.7.4.2 22000
-
 x * 22000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
2.7.4.2 Homo sapiens Q15126
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
2.7.4.2 Ni-Sepharose column chromatography Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.7.4.2 ATP + (R)-5-phosphomevalonate
-
 Homo sapiens ADP + (R)-5-diphosphomevalonate
-
 ?

Subunits

EC Number Subunits Comment Organism
2.7.4.2 ? x * 22000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
2.7.4.2 PMK
-
 Homo sapiens