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Literature summary extracted from

  • Grove, T.H.; Ishaque, A.; Levy, H.R.
    Glucose-6-phosphate dehydrogenase from Leuconostoc mesenteroides. Interaction of the enzyme with coenzymes and coenzyme analogs (1976), Arch. Biochem. Biophys., 17, 307-316.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.1.1.363 2',5'-ADP NADP+-competitive and NAD+-noncompetitive inhibition Leuconostoc mesenteroides
1.1.1.363 2'-AMP
-
 Leuconostoc mesenteroides
1.1.1.363 5'-AMP
-
 Leuconostoc mesenteroides
1.1.1.363 adenosine
-
 Leuconostoc mesenteroides
1.1.1.363 ADP
-
 Leuconostoc mesenteroides
1.1.1.363 ADP-ribose
-
 Leuconostoc mesenteroides
1.1.1.363 ATP
-
 Leuconostoc mesenteroides
1.1.1.363 D-glucose 1-phosphate a substrate-competitive inhibitor, that lowers the dissociation constant and maximum fluorescence quenching for NAD+ but not for NADP+ Leuconostoc mesenteroides
1.1.1.363 N'-methylnicotinamide
-
 Leuconostoc mesenteroides
1.1.1.363 nicotinamide
-
 Leuconostoc mesenteroides

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.363 D-glucose 6-phosphate + NAD+ Leuconostoc mesenteroides
-
 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
 ?
1.1.1.363 D-glucose 6-phosphate + NADP+ Leuconostoc mesenteroides
-
 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.363 Leuconostoc mesenteroides
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.1.1.363
-
 Leuconostoc mesenteroides

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.363 D-glucose 6-phosphate + NAD+
-
 Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADH + H+
-
 ?
1.1.1.363 D-glucose 6-phosphate + NADP+
-
 Leuconostoc mesenteroides 6-phospho-D-glucono-1,5-lactone + NADPH + H+
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.363 NAD+ the maximum quenching of protein fluorescence is 50% for NAD+. The dissociation constant for NAD+ is 2.5 mM Leuconostoc mesenteroides
1.1.1.363 NADP+ the maximum quenching of protein fluorescence is 5% for NADP+. The dissociation constant for NADP+ is 0.003 mM Leuconostoc mesenteroides

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.1.1.363 0.12
-
 2',5'-ADP pH 7.8, 25°C, substrate: NADP+ Leuconostoc mesenteroides
1.1.1.363 0.52
-
 ADP-ribose pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.1.1.363 1.3
-
 2'-AMP pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.1.1.363 1.5
-
 ATP pH 7.8, 25°C, substrate: NADP+ Leuconostoc mesenteroides
1.1.1.363 2
-
 5'-AMP pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.1.1.363 3.1
-
 ADP pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.1.1.363 36
-
 adenosine pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.1.1.363 95
-
 N'-methylnicotinamide pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides
1.1.1.363 105
-
 nicotinamide pH 7.8, 25°C, substrate: NAD+ Leuconostoc mesenteroides