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Literature summary extracted from

  • Yang, F.; Zhang, S.; Zhou, Y.J.; Zhu, Z.; Lin, X.; Zhao, Z.K.
    Characterization of the mitochondrial NAD+-dependent isocitrate dehydrogenase of the oleaginous yeast Rhodosporidium toruloides (2012), Appl. Microbiol. Biotechnol., 94, 1095-1105.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.1.1.41 gene RtIDH1, DNA and amino acid sequence determination and analysis, sequence comparison, expression in the Saccharomyces cerevisiae strain BY4741 idhDELTA mutant, RtIdh expression leads to increased intracellular lipid content and extracellular citrate concentration with increasing carbon/nitrogen molar ratio of the media under nitrogen limiting conditions Rhodotorula toruloides
1.1.1.41 gene RtIDH2, DNA and amino acid sequence determination and analysis, sequence comparison, expression in the Saccharomyces cerevisiae strain BY4741 idhDELTA mutant, RtIdh expression leads to increased intracellular lipid content and extracellular citrate concentration with increasing carbon/nitrogen molar ratio of the media under nitrogen limiting conditions Rhodotorula toruloides

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.1.1.41 mitochondrion
-
 Rhodotorula toruloides 5739
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.1.1.41 isocitrate + NAD+ Rhodotorula toruloides
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?
1.1.1.41 isocitrate + NAD+ Rhodotorula toruloides AS 2.1389
-
 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.1.1.41 Rhodotorula toruloides G1APK2 gene RtIDH1; gene RtIDH1
-
1.1.1.41 Rhodotorula toruloides G1APK3 gene RtIDH2; gene RtIDH2
-
1.1.1.41 Rhodotorula toruloides AS 2.1389 G1APK2 gene RtIDH1; gene RtIDH1
-
1.1.1.41 Rhodotorula toruloides AS 2.1389 G1APK3 gene RtIDH2; gene RtIDH2
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.1.1.41 isocitrate + NAD+
-
 Rhodotorula toruloides 2-oxoglutarate + CO2 + NADH + H+
-
 ?
1.1.1.41 isocitrate + NAD+
-
 Rhodotorula toruloides AS 2.1389 2-oxoglutarate + CO2 + NADH + H+
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.1.1.41 IDH
-
 Rhodotorula toruloides
1.1.1.41 NAD+-dependent isocitrate dehydrogenase
-
 Rhodotorula toruloides
1.1.1.41 NAD+-specific IDH
-
 Rhodotorula toruloides

Cofactor

EC Number Cofactor Comment Organism Structure
1.1.1.41 NAD+ dependent on Rhodotorula toruloides

General Information

EC Number General Information Comment Organism
1.1.1.41 metabolism regulatory controls of key enzymes during microbial lipid accumulation involving the enzyme, overview Rhodotorula toruloides