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Literature summary extracted from

  • Yu, J.; Chang, P.K.; Cary, J.W.; Bhatnagar, D.; Cleveland, T.E.
    avnA, a gene encoding a cytochrome P-450 monooxygenase, is involved in the conversion of averantin to averufin in aflatoxin biosynthesis in Aspergillus parasiticus (1997), Appl. Environ. Microbiol., 63, 1349-1356.
    View publication on PubMedView publication on EuropePMC

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.14.14.116 56300
-
 x * 56300, calculated from amino acid sequence Aspergillus parasiticus
1.14.14.116 56300
-
 x * 56300, calculated from sequence Aspergillus parasiticus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus SU1-N3 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus SU1-N3 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus
-
 5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 averantin + [reduced NADPH-hemoprotein reductase] + O2 Aspergillus parasiticus SRRC 143
-
 5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.14.116 Aspergillus parasiticus
-
 ATCC 56775
-
1.14.14.116 Aspergillus parasiticus Q12732
-
-
1.14.14.116 Aspergillus parasiticus SRRC 143
-
 ATCC 56775
-
1.14.14.116 Aspergillus parasiticus SU1-N3 Q12732
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus SU1-N3 (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus SU1-N3 (1'S,5'R)-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme catalyzes a reaction in the aflatoxin biosynthesis pathway. It specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus SU1-N3 (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 (1'S)-averantin + [reduced NADPH-hemoprotein reductase] + O2 the enzyme specifically hydroxylates (1'S)-averantin to the diastereomers (1'S,5'R)-hydroxyaverantin and (1'S,5'S)-hydroxyaverantin Aspergillus parasiticus SU1-N3 (1'S,5'S)-5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 averantin + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus parasiticus 5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?
1.14.14.116 averantin + [reduced NADPH-hemoprotein reductase] + O2
-
 Aspergillus parasiticus SRRC 143 5'-hydroxyaverantin + [oxidized NADPH-hemoprotein reductase] + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.14.14.116 ? x * 56300, calculated from amino acid sequence Aspergillus parasiticus
1.14.14.116 ? x * 56300, calculated from sequence Aspergillus parasiticus

Synonyms

EC Number Synonyms Comment Organism
1.14.14.116 avnA
-
 Aspergillus parasiticus
1.14.14.116 avnA gene name, previously named ord-1 Aspergillus parasiticus
1.14.14.116 CYP60A1
-
 Aspergillus parasiticus

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.14.116 cytochrome P450 a cytochrome P-450-type monooxygenase Aspergillus parasiticus

General Information

EC Number General Information Comment Organism
1.14.14.116 malfunction disruption of the avnA gene in the wild type aflatoxigenic Aspergillus parasiticus strain SU1-N3 results in a nonaflatoxigenic mutant which accumulates a bright yellow pigment. Norsolorinic acid and averantin are not converted to aflatoxin by the mutant whereas 5'-hydroxyaverantin, averufanin, averufin, versicolorin A, sterigmatocystin, and O-methylsterigmatocystin are converted to aflatoxins Aspergillus parasiticus
1.14.14.116 metabolism the enzyme is involved in the conversion of averantin to averufin in the aflatoxin biosynthetic pathway Aspergillus parasiticus