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Literature summary extracted from

  • Hudson, S.; McLean, K.; Surade, S.; Yang, Y.; Leys, D.; Ciulli, A.; Munro, A.; Abell, C.
    Application of fragment screening and merging to the discovery of inhibitors of the Mycobacterium tuberculosis cytochrome P450 CYP121 (2012), Angew. Chem. Int. Ed. Engl., 51, 9311-9316.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.14.19.70 2-methylquinolin-6-amine
-
 Mycobacterium tuberculosis
1.14.19.70 3-(1H-1,2,4-triazol-1-ylmethyl)aniline
-
 Mycobacterium tuberculosis
1.14.19.70 4,4'-(1H-1,2,3-triazole-1,4-diyl)diphenol
-
 Mycobacterium tuberculosis
1.14.19.70 4,4'-(1H-1,2,3-triazole-1,5-diyl)diphenol
-
 Mycobacterium tuberculosis
1.14.19.70 4-(1,3-thiazol-5-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
1.14.19.70 4-(1H-1,2,3-triazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
1.14.19.70 4-(1H-1,2,4-triazol-1-yl)phenol
-
 Mycobacterium tuberculosis
1.14.19.70 4-(1H-1,2,4-triazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
1.14.19.70 4-(1H-1,2,4-triazol-1-yl)quinoline
-
 Mycobacterium tuberculosis
1.14.19.70 4-(1H-imidazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
1.14.19.70 4-(1H-pyrazol-1-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
1.14.19.70 4-(4-phenoxy-1H-pyrazol-3-yl)benzene-1,3-diol
-
 Mycobacterium tuberculosis
1.14.19.70 4-(pyridin-3-yl)quinolin-6-amine
-
 Mycobacterium tuberculosis
1.14.19.70 4-oxo-4,5,6,7-tetrahydro-1-benzofuran-3-carboxylic acid
-
 Mycobacterium tuberculosis
1.14.19.70 4-[4-(4-fluorophenyl)-1H-pyrazol-3-yl]benzene-1,3-diol
-
 Mycobacterium tuberculosis
1.14.19.70 4-[4-(4-methoxyphenyl)-1H-pyrazol-3-yl]benzene-1,3-diol
-
 Mycobacterium tuberculosis
1.14.19.70 6-nitro-4-(1H-1,2,4-triazol-1-yl)quinoline
-
 Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2 Mycobacterium tuberculosis H37Rv
-
 mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.14.19.70 Mycobacterium tuberculosis P9WPP7
-
-
1.14.19.70 Mycobacterium tuberculosis H37Rv P9WPP7
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?
1.14.19.70 cyclo(L-tyrosyl-L-tyrosyl) + 2 reduced ferredoxin [iron-sulfur] cluster + 2 H+ + O2
-
 Mycobacterium tuberculosis H37Rv mycocyclosin + 2 oxidized ferredoxin [iron-sulfur] cluster + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.14.19.70 CYP121
-
 Mycobacterium tuberculosis

Cofactor

EC Number Cofactor Comment Organism Structure
1.14.19.70 heme
-
 Mycobacterium tuberculosis